133371 event 1338462369 1475891937 Eli Fine - Advisor, Gang Bao, PhD

"Detecting Off-Target Effects of Engineered Nucleases"

Targeted cleavage of DNA by engineered nucleases, such as ZFNs and TALENs, has been used to edit the genomes of many plants and animals. Nucleases can knock-in or knock-out specific genes as well as correct mutations. A major concern in their use is the possibility of cleavage at locations other than the target site. A novel method of locating off-target events and an investigation of the off-target profiles of several nucleases are presented.

Nicholas Parnell - Advisor, J. Todd Streelman, PhD

"Investigating the Genetic and Developmental Basis of Teeth and Taste Buds"

Teeth and taste buds provide an interesting model of iterative development because their anatomical fields may overlap within the oral cavity. To investigate the genetic and developmental components of tooth and taste bud densities we use the diverse and rapidly radiating cichlid fishes of Lake Malawi, Africa. By combining quantitative genetics with molecular biology we are gaining insights into the process of co-patterning oral structures.

]]> The Graduate and Post-Doc (GaP) Seminar Series is a weekly event of research presentations by two graduate students or post-docs conducting bio-related research.  The series is organized and sponsored by the Parker H. Petit Institute for Bioengineering and Bioscience (IBB) with additional support from the Wallace H. Coulter Department of Biomedical Engineering. It is held every Wednesday at 12:00pm in IBB 1128 and refreshments are provided. If your research group or department would like to present at future seminars, please contact Manu Platt, PhD.

]]> 65807 image 192409 image/png 151321 image 195192 image/png 154441 image 195256 image/png Manu Platt, PhD

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