{"136351":{"#nid":"136351","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Engineering the Innate Immune Response to Infection\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EScott Simon, PhD\u003Cbr \/\u003EUniversity of California, Davis\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPolymorphonuclear (PMN) leukocytes are critical in the innate immune response against pathogens. The most frequent cause of non-healing skin wounds and infectious arthritis is due to Staphylococcus aureus (SA) infections. In particular, PMN recruitment and abscess formation is a hallmark of these infections and is required for bacterial clearance. Recent published data from our laboratory indicates that strategic manipulation of the inflammatory response of PMN at the site of a cutaneous wound can suppress infection and improve the efficiency of non-scar healing. These studies employed non-invasive whole animal fluorescence imaging of genetically tagged EGFPPMN mice, which provide a real-time multiparameter readout of the dynamic changes in PMN recruitment and lifetime, SA burden, and wound closure. A novel finding is that\u0026nbsp;PMN and hematopoietic stem and progenitor cell (HSPC) recruitment and function in the\u0026nbsp;abscess can be engineered to\u0026nbsp;optimize clearance of microbial infections and prevent aberrant\u0026nbsp;inflammation that delays\u0026nbsp;normal tissue healing. This seminar will discuss a bioengineering systems approach to guide the innate immune response for improving resolution of a persistent SA infection in a mouse model of tissue injury.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between IBB and the BME department. Seminars\u0026nbsp;are held on Tuesdays or Thursdays between 11am-12pm in IBB room 1128 unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineering the Innate Immune Response to Infection\u0022-  Scott Simon, PhD - University of California, Davis"}],"uid":"27691","created_gmt":"2012-06-19 11:20:06","changed_gmt":"2016-10-08 01:59:07","author":"Karen Cannon","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-11-15T10:00:00-05:00","event_time_end":"2012-11-15T11:00:00-05:00","event_time_end_last":"2012-11-15T11:00:00-05:00","gmt_time_start":"2012-11-15 15:00:00","gmt_time_end":"2012-11-15 16:00:00","gmt_time_end_last":"2012-11-15 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"136581":{"id":"136581","type":"image","title":"Scott Simon, PhD - UC Davis","body":null,"created":"1449178685","gmt_created":"2015-12-03 21:38:05","changed":"1475894766","gmt_changed":"2016-10-08 02:46:06","alt":"Scott Simon, PhD - UC Davis","file":{"fid":"194825","name":"simon2.jpg","image_path":"\/sites\/default\/files\/images\/simon2_0.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/simon2_0.jpg","mime":"image\/jpeg","size":176228,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/simon2_0.jpg?itok=LkdUhN1g"}},"141991":{"id":"141991","type":"image","title":"Bioengineering Seminar Series","body":null,"created":"1449178723","gmt_created":"2015-12-03 21:38:43","changed":"1475894774","gmt_changed":"2016-10-08 02:46:14","alt":"Bioengineering Seminar Series","file":{"fid":"194960","name":"website-graphic.png","image_path":"\/sites\/default\/files\/images\/website-graphic_0.png","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/website-graphic_0.png","mime":"image\/png","size":334882,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/website-graphic_0.png?itok=IXDOvvwR"}}},"media_ids":["136581","141991"],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/bioe-seminars","title":"BIOE Seminar Series schedule"},{"url":"http:\/\/www.bme.ucdavis.edu\/simonlab\/","title":"Simon Lab Website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"36591","name":"Bioengeneering Seminar Series"},{"id":"248","name":"IBB"},{"id":"167676","name":"Scott Simon"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:barabino@gatech.edu\u0022\u003EGilda Barabino, PhD,\u003C\/a\u003E\u0026nbsp;faculty host\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}