{"316131":{"#nid":"316131","#data":{"type":"event","title":"How Small Fish Help Predict Human Risk from Non-Dioxin like PCBs","body":[{"value":"\u003Cp\u003EJohn Stegeman, PhD\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe NIEHS Superfund Research Program \u0026amp; NCEH\/ATSDR Office of Science present\u003Cbr \/\u003E\u003Cstrong\u003EHow Small Fish Help Predict Human Risk from Non-Dioxin like PCBs\u003C\/strong\u003E\u003Cbr \/\u003EJohn Stegeman, PhD\u003Cbr \/\u003EBoston University Superfund Research Center \u0026amp; Director, Center for Oceans and Human Health Woods Hole Oceanographic Institution Animal models have long been used to identify and understand how chemicals contribute to disease processes. Over the past 15 years, efforts involving small fish models have focused most on the zebrafish (eol.org\/pages\/204011\/overview), but there is renewed interest in other species including the estuarine killifish Fundulus heteroclitis (eol.org\/pages\/1157172\/overview). Fish models are helping to decipher the molecular mechanisms by which dioxins and dioxin-like chemicals including non-ortho polychlorinated biphenyls (PCBs)\u003Cbr \/\u003Ecause toxicity, especially during development, and to uncover mechanisms of resistance to that toxicity. But what about the non-dioxin-like (NDL) ortho-PCBs? Our understanding of the toxicity and the mechanisms by which these chemicals are toxic is still fragmentary. Do ortho-PCBs have similar effects in mammals and fish? Can small fish provide insights into such mechanisms, as they have for the dioxin-like compounds? Our gene\u003Cbr \/\u003Eexpression studies with ortho-PCBs in zebrafish are highlighting pathways of response to the NDL PCBs, including induction of P450s via the pregnane X receptor (PXR), as yet a poorly understood participant in NDL-chemical effects in fish. Our studies also point to novel molecular targets that may participate in causing the neurobehavioral effects of NDL PCBs. In the killifish, our results suggest that multigenerational exposure to very\u003Cbr \/\u003Ehigh levels of NDL PCBs causes adaptation by altering the function of calcium channels. This raises questions about whether structurally similar persistent environmental chemicals may cause similar effects. We should soon better understand the similarities and differences involved in different species\u2019 responses to NDL compounds.\u003C\/p\u003E\u003Cp\u003E*Local partners outside CDC\/ATSDR who wish to attend in person may contact \u003Ca href=\u0022mailto:OHarris@cdc.gov\u0022\u003EOHarris@cdc.gov\u003C\/a\u003E for security clearance (1 week notice for US citizens; 3 weeks for non-citizens).\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"How Small Fish Help Predict Human Risk from Non-Dioxin like PCBs"}],"uid":"27964","created_gmt":"2014-08-15 13:09:46","changed_gmt":"2017-04-13 21:22:03","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-09T11:00:00-04:00","event_time_end":"2014-09-09T12:30:00-04:00","event_time_end_last":"2014-09-09T12:30:00-04:00","gmt_time_start":"2014-09-09 15:00:00","gmt_time_end":"2014-09-09 16:30:00","gmt_time_end_last":"2014-09-09 16:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"123","name":"CDC"},{"id":"100001","name":"John Stegeman"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EOlivia Harris at 770-488-0597 or \u003Ca href=\u0022mailto:OHarris@cdc.gov\u0022\u003EOHarris@cdc.gov\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E*Local partners outside CDC\/ATSDR must have security clearence (1 week notice for US citizens; 3 weeks for non-citizens) to attend in person. You may contact \u003Ca href=\u0022mailto:OHarris@cdc.gov\u0022\u003EOHarris@cdc.gov\u003C\/a\u003E for security clearance.\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}