{"342651":{"#nid":"342651","#data":{"type":"event","title":"PhD Proposal by Caitlin Martin","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ECaitlin Martin\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPhD Proposal Presentation\u003C\/p\u003E\u003Cp\u003EDate:\u0026nbsp;Friday\u0026nbsp;November\u0026nbsp;14th, 2014\u003C\/p\u003E\u003Cp\u003ETime: 3:00pm\u003C\/p\u003E\u003Cp\u003ELocation: TEP 104\u003C\/p\u003E\u003Cp\u003EThesis\u0026nbsp;committee\u0026nbsp;members:\u003C\/p\u003E\u003Cp\u003EAdvisor: Wei\u0026nbsp;Sun, Ph.D. (BME)\u003Cbr \/\u003EJohn Elefteriades, M.D. (Yale)\u003Cbr \/\u003EAjit Yoganathan, Ph.D. (BME)\u003Cbr \/\u003EGang Bao, Ph.D. (ME)\u003Cbr \/\u003EMuralidhar Padala, Ph.D. (Emory)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003ETitle:\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EModeling and simulation of time-dependent inelastic soft tissue behavior\u003C\/strong\u003E.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESoft tissues undergo irreversible microstructural changes over time including elastin degradation and collagen fiber un-crimping, which are realized on the tissue level by dilation and reduced compliance. These changes can be brought on by mechanical loading and the natural aging process, and accelerated by disease.\u0026nbsp;\u0026nbsp;However, the roles of mechanical and environmental factors on the progression of permanent tissue property changes are not well understood.\u0026nbsp;\u0026nbsp;Most of the biomechanics work on soft tissues reported in the literature thus far, whether experimental, theoretical, or computational, is confined to static, instantaneous tissue property characterization.\u0026nbsp;\u0026nbsp;As such, only the recoverable or\u0026nbsp;\u003Cem\u003Eelastic\u003C\/em\u003E\u0026nbsp;behavior of tissue is considered, although from a thermodynamics stand point, permanent changes in tissue structure and material properties represent dissipative,\u0026nbsp;\u003Cem\u003Einelastic\u003C\/em\u003E\u0026nbsp;effects.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThe objective of this study is to develop a theoretical and computational framework to describe the inelastic behavior of soft tissues such that the effects of mechanical fatigue damage and aging in soft tissues can be accurately modeled.\u0026nbsp;\u0026nbsp;\u003C\/strong\u003EA theoretical framework based on thermoelastic theory with internal variables will be developed to describe the irreversible accumulation of damage and permanent set in soft tissues over time.\u0026nbsp;\u0026nbsp;The theoretical framework will then be implemented in finite element to investigate leaflet fatigue damage in bioprosthetic heart valves and age-related changes in the ascending aorta.\u0026nbsp;\u0026nbsp;The results from these studies may offer scientific rationale for the design of durable tissue-based devices and improved diagnostic methods.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Modeling and simulation of time-dependent inelastic soft tissue behavior"}],"uid":"28077","created_gmt":"2014-11-06 17:23:11","changed_gmt":"2016-10-08 02:10:09","author":"Danielle Ramirez","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-14T14:00:00-05:00","event_time_end":"2014-11-14T16:00:00-05:00","event_time_end_last":"2014-11-14T16:00:00-05:00","gmt_time_start":"2014-11-14 19:00:00","gmt_time_end":"2014-11-14 21:00:00","gmt_time_end_last":"2014-11-14 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"1808","name":"graduate students"},{"id":"913","name":"PhD"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}