{"400101":{"#nid":"400101","#data":{"type":"event","title":"PhD Defense by Jason Lamanna","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EJason Lamanna\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EPhD Thesis Defense\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EMonday, May 11\u003Csup\u003Eth\u003C\/sup\u003E, 2015 at 9am\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EEmory University Health Sciences Research Building (HSRB) Room E160\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAdvisors: Nicholas Boulis, MD and John Oshinski, PhD\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee Members: Jacques Galipeau, MD; Shawn Hochman, PhD; Shella Keilholz, PhD\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMagnetic Resonance Imaging of Intraspinal Stem Cell Grafts: Tracking and Targeted Transplantation\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003ETransplantation of cellular therapeutics into the spinal cord has been explored as treatment for a range of degenerative and traumatic diseases. The post-transplantation fate of cellular therapeutics is poorly understood in both large animal models and in human studies because of limitations in cell graft detection. A minimally invasive technology for cellular graft tracking to visualize grafts in vivo is needed. However, it is important that the diagnostic marker does not impact the engraftment or efficacy of transplanted cells.\u0026nbsp; We aim to develop a straightforward, rapidly translatable method to label human neural progenitor\/stem cells with magnetic ferumoxytol nanoparticles.\u0026nbsp; We investigate the potential effect of ferumoxytol labeling on biological properties of the cells and transplant them into a large animal (porcine) spinal cord.\u0026nbsp; We assess the feasibility and safety of in vivo diagnostic cell graft tracking using Magnetic Resonance Imaging and post-mortem histological identification in a clinically relevant model.\u0026nbsp; Furthermore, we leverage this tracking approach to develop and assess a minimally invasive, Magnetic Resonance Imaging-guided technique for targeted intraspinal stem cell graft transplantation in a large animal model.\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Magnetic Resonance Imaging of Intraspinal Stem Cell Grafts: Tracking and Targeted Transplantation"}],"uid":"27707","created_gmt":"2015-04-28 10:41:16","changed_gmt":"2016-10-08 02:11:54","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-11T10:00:00-04:00","event_time_end":"2015-05-11T12:00:00-04:00","event_time_end_last":"2015-05-11T12:00:00-04:00","gmt_time_start":"2015-05-11 14:00:00","gmt_time_end":"2015-05-11 16:00:00","gmt_time_end_last":"2015-05-11 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"1366","name":"defense"},{"id":"1808","name":"graduate students"},{"id":"913","name":"PhD"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}