{"412551":{"#nid":"412551","#data":{"type":"event","title":"Wallace H. Coulter Distinguished Lecture in Biomedical Engineering","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EWallace H. Coulter Distinguished Lecture in Biomedical Engineering\u003Cbr \/\u003E\u0022Deciphering the Dynamics of the Unconscious Brain Under General Anesthesia\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EEmery Brown, M.D., Ph.D.\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EInstitute for Medical Engineering and Science\u003Cbr \/\u003EDepartment of Brain and Cognitive Sciences\u003Cbr \/\u003EMassachusetts Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003EDepartment of Anesthesia, Critical Care and Pain Medicine\u003Cbr \/\u003EMassachusetts General Hospital\u003Cbr \/\u003EHarvard Medical School\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EABSTRACT\u003C\/p\u003E\u003Cp\u003EGeneral anesthesia is a drug-induced, reversible condition comprised of five behavioral states: unconsciousness, amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and hemodynamic stability with control of the stress response. The mechanisms by which anesthetic drugs induce the state of general anesthesia are considered one of the biggest mysteries of modern medicine. We study four problems to decipher this mystery. First, we present findings from our human studies of general anesthesia using high-density EEG and intracranial recordings which have allowed us to give a detailed characterization of the neurophysiology of loss and recovery of consciousness due to the standard anesthetics. Second, we show how the response to anesthesia changes as a function of age. Third, we present a neuro-metabolic model of burst suppression, the profound state of brain inactivation seen in deep states of general anesthesia. We show that our characterization of burst suppression can be used to design a closed-loop anesthesia delivery system for control of a medically-induced coma. Finally, we demonstrate that the state of general anesthesia can be rapidly reversed by activating specific brain circuits. Our results show that it is now possible to have a detailed neurophysiological understanding of the brain under general anesthesia, and that this understanding can be used to precisely monitor and control anesthetic states. Hence, general anesthesia is not a mystery.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFaculty Host:\u0026nbsp;\u003Ca href=\u0022mailto:garrett.stanley@bme.gatech.edu\u0022\u003EGarrett Stanley\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Wallace H. Coulter Distinguished Lecture in Biomedical Engineering\u0026nbsp;is an annual presentation of high-impact research from top-tier researchers.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Deciphering the Dynamics of the Unconscious Brain Under General Anesthesia\u0022 - Emery Brown, MIT\/Harvard"}],"uid":"27513","created_gmt":"2015-06-09 12:17:38","changed_gmt":"2017-04-13 21:19:13","author":"Walter Rich","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-10-29T17:00:00-04:00","event_time_end":"2015-10-29T19:00:00-04:00","event_time_end_last":"2015-10-29T19:00:00-04:00","gmt_time_start":"2015-10-29 21:00:00","gmt_time_end":"2015-10-29 23:00:00","gmt_time_end_last":"2015-10-29 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/www.bme.gatech.edu\/bme\/faculty\/Garrett-B.-Stanley","title":"Profile: Garrett Stanley"},{"url":"https:\/\/sleep.med.harvard.edu\/people\/faculty\/150\/Emery+N+Brown+MD+PhD","title":"Profile: Emery Brown"}],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"7723","name":"Academy of Medicine"},{"id":"249","name":"Biomedical Engineering"},{"id":"946","name":"distinguished lecture"},{"id":"126591","name":"go-NeuralEngineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty Host: \u003Ca href=\u0022mailto:garrett.stanley@bme.gatech.edu\u0022\u003EGarrett Stanley\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}