{"412961":{"#nid":"412961","#data":{"type":"event","title":"PhD Defense by Ashley Allen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAshley Allen\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPh.D. Defense Presentation\u003C\/p\u003E\u003Cp\u003EWednesday, June 24, 2015, 9:00am\u003Cbr \/\u003E Petit Institute Suddath Seminar Room (IBB 1128)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E\u003Cbr \/\u003E Robert E. Guldberg, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E \u003Cbr \/\u003E \u003Cstrong\u003ECommittee\u003C\/strong\u003E\u003Cbr \/\u003E Ian B. Copland, PhD. (Emory University)\u003Cbr \/\u003E Andr\u00e9s J. Garc\u00eda, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EZulma Gazit, Ph.D. (Cedars-Sinai Medical Center)\u003Cbr \/\u003E Todd C. McDevitt, Ph.D. (Gladstone Institutes)\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E \u003Cstrong\u003EModulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ELarge bone defects, such as those resulting from trauma or tumor resection, are repaired using graft tissue as the current gold standard. However, limitations of this treatment approach, including limited tissue availability and poor revascularization post-grafting, have motivated the development of cell- and protein-based strategies. Although recombinant human bone morphogenetic protein 2 (rhBMP-2) is clinically utilized to promote bone repair in incidences of non-union, supra-physiologic dosing of rhBMP-2 can result in adverse effects including heterotopic bone formation and systemic inflammation. Mesenchymal stem cell (MSC)-based bone tissue engineering strategies offer several potential advantages over the use of osteoinductive protein alone. However, challenges to control delivered cell behavior remain a significant barrier to the clinical translation of MSC-based therapeutics. \u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EHuman platelet lysate (hPL) utilization and cell aggregation have each demonstrated the capacity to modulate a range of MSC outcomes, including cell number, phenotype, and secretome. The goal of this work was to investigate their potential application in MSC-based large bone defect repair. We pursued this objective through development of a bioluminescent cell tracking protocol and subsequent evaluation of these strategies for improved MSC survival and facilitated bone regeneration. Additional to engineering an efficacious MSC-based treatment for bone injury, this research aimed to relate key principles influencing cell-based tissue regeneration more globally. \u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E \u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Modulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration"}],"uid":"27707","created_gmt":"2015-06-10 10:00:03","changed_gmt":"2016-10-08 02:12:14","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-06-24T10:00:00-04:00","event_time_end":"2015-06-24T12:00:00-04:00","event_time_end_last":"2015-06-24T12:00:00-04:00","gmt_time_start":"2015-06-24 14:00:00","gmt_time_end":"2015-06-24 16:00:00","gmt_time_end_last":"2015-06-24 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"1366","name":"defense"},{"id":"1808","name":"graduate students"},{"id":"913","name":"PhD"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}