{"46361":{"#nid":"46361","#data":{"type":"news","title":"Researchers Identify Genes for Thiostrepton, a Powerful Antibiotic","body":[{"value":"\u003Cp\u003EResearchers at the Georgia Institute of Technology have identified the genetic machinery responsible for synthesizing thiostrepton, a powerful antibiotic produced by certain bacteria.  Though effective against the dangerous MRSA (methicillin-resistant \u003Cem\u003EStaphylococcus aureus\u003C\/em\u003E) and vancomycin-resistant enterococci, thiostrepton currently has only limited applications in humans because it is not water soluble.  \u003C\/p\u003E\n\u003Cp\u003EIdentification of the gene cluster responsible for producing thiostrepton sets the stage for genetic manipulations that could make the drug more useful by improving its water solubility, potentially providing a new tool in the high-stakes battle against bacteria.  Beyond the possible medical applications, the research produced a scientific surprise: thiostrepton is derived from a genetically encoded peptide that undergoes no fewer than 19 different modifications, one of the most complex such processes known\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":[{"value":"Work Could Set Stage for Making the Drug More Useful"}],"field_summary":[{"value":"Researchers have identified the genetic machinery responsible for synthesizing thiostrepton, a powerful antibiotic produced by certain bacteria. The drug is effective against the dangerous MRSA (methicillin-resistant Staphylococcus aureus) and vancomycin-resistant enterococci.","format":"limited_html"}],"field_summary_sentence":[{"value":"Gene isolation could lead to improved antibiotic"}],"uid":"27303","created_gmt":"2009-03-23 00:00:00","changed_gmt":"2016-10-08 03:03:14","author":"John Toon","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-03-23T00:00:00-04:00","iso_date":"2009-03-23T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"46362":{"id":"46362","type":"image","title":"Thiostrepton \u0026 researchers","body":null,"created":"1449174401","gmt_created":"2015-12-03 20:26:41","changed":"1475894416","gmt_changed":"2016-10-08 02:40:16","alt":"Thiostrepton \u0026 researchers","file":{"fid":"101125","name":"tjb37704.jpg","image_path":"\/sites\/default\/files\/images\/tjb37704_0.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tjb37704_0.jpg","mime":"image\/jpeg","size":1454826,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tjb37704_0.jpg?itok=DuAo6p8g"}},"46363":{"id":"46363","type":"image","title":"Thiostrepton \u0026 researchers","body":null,"created":"1449174401","gmt_created":"2015-12-03 20:26:41","changed":"1475894416","gmt_changed":"2016-10-08 02:40:16","alt":"Thiostrepton \u0026 researchers","file":{"fid":"101126","name":"tkd37704.jpg","image_path":"\/sites\/default\/files\/images\/tkd37704_0.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tkd37704_0.jpg","mime":"image\/jpeg","size":1233972,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tkd37704_0.jpg?itok=w97BQM3M"}},"46364":{"id":"46364","type":"image","title":"Wendy Kelly","body":null,"created":"1449174401","gmt_created":"2015-12-03 20:26:41","changed":"1475894416","gmt_changed":"2016-10-08 02:40:16","alt":"Wendy Kelly","file":{"fid":"101127","name":"tad37704.jpg","image_path":"\/sites\/default\/files\/images\/tad37704_0.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tad37704_0.jpg","mime":"image\/jpeg","size":821403,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tad37704_0.jpg?itok=qP5qlfM2"}}},"media_ids":["46362","46363","46364"],"related_links":[{"url":"http:\/\/www.chemistry.gatech.edu\/","title":"School of Chemistry and Biochemistry"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"},{"url":"http:\/\/www.chemistry.gatech.edu\/faculty\/Kelly\/","title":"Wendy Kelly"}],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"1109","name":"antibiotic"},{"id":"1110","name":"gene"},{"id":"1112","name":"MRSA"},{"id":"1113","name":"peptide"},{"id":"1111","name":"thiostrepton"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EJohn Toon\u003C\/strong\u003E\u003Cbr \/\u003EResearch News \u0026amp; Publications Office\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=jt7\u0022\u003EContact John Toon\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-6986\u003C\/strong\u003E","format":"limited_html"}],"email":["jtoon@gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}