{"466201":{"#nid":"466201","#data":{"type":"news","title":"INFORMS Presents Wagner Prize for Matching Vaccines \u0026 Genes to Optimize Vaccine Effectiveness to CDC, Georgia Tech, Emory University","body":[{"value":"\u003Ch5 class=\u0022 text-left\u0022\u003EPointer to Designing a Universal Flu Vaccine\u003C\/h5\u003E\u003Cp\u003EPHILADELPHIA, PA, November 4, 2015 \u2013 The Institute for Operations Research and the Management Sciences (\u003Ca href=\u0022http:\/\/www.informs.orINFORMS\u0022 target=\u0022_self\u0022\u003EINFORMS\u003C\/a\u003E\u003Csup\u003E\u00ae\u003C\/sup\u003E), the leading professional association in analytics and operations research, today announced that the winner of the Daniel H. Wagner Prize is a team comprising researchers from the CDC, Georgia Tech, and Emory University for creating a model that uses genetic signatures to predict the efficacy of vaccines on an individual by individual basis.\u003C\/p\u003E\u003Cp\u003EThe winner of the INFORMS Daniel H. Wagner Prize competition was named on Tuesday, November 3 at the \u003Ca href=\u0022http:\/\/meetings2.informs.org\/wordpress\/philadelphia\/\u0022 target=\u0022_self\u0022\u003E2015 INFORMS Annual Meeting in Philadelphia\u003C\/a\u003E. The competition is judged by CPMS, the association\u2019s practice section. Over 5,500 academics and practitioners attended the conference.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMachine Learning Framework for Predicting Vaccine Immunogenicity, \u003C\/strong\u003Eis by Eva K. Lee, Fan Yuan, Georgia University of Technology; Bali Pulendran, Helder Nakaya, Emory University; and Ferdinand Pietz and Bernard Benecke, Centers for Disease Control and Prevention.\u003C\/p\u003E\u003Cp\u003EEva K. Lee is the winner of numerous INFORMS awards. \u003Ca href=\u0022https:\/\/www.informs.org\/About-INFORMS\/News-Room\/Press-Releases\/2015-INFORMS-Fellows\u0022 target=\u0022_self\u0022\u003EShe was named an INFORMS Fellow \u003C\/a\u003Eat the INFORMS annual meeting.\u003C\/p\u003E\u003Cp\u003EThe ability to better predict how different individuals will respond to vaccination and to understand what best protects them from infection marks an important advance in developing next-generation vaccines. It facilitates the rapid design and evaluation of new and emerging vaccines. It also identifies individuals unlikely to benefit from the vaccine.\u003C\/p\u003E\u003Cp\u003EThe authors created a general-purpose machine learning framework, called DAMIP, for discovering gene signatures that can predict vaccine immunity and efficacy. \u0026nbsp;\u003C\/p\u003E\u003Cp\u003EUsing DAMIP, implemented results for yellow fever demonstrated that, for the first time, a vaccine\u2019s ability to immunize a patient could be successfully predicted with greater than 90% accuracy within a week after vaccination. A gene identified by DAMIP decrypted a seven-decade-old mystery of vaccination. Results for flu vaccine demonstrated DAMIP\u2019s applicability to both live-attenuated and inactivated vaccines. Similar results in a malaria study enabled targeted delivery to individual patients.\u003C\/p\u003E\u003Cp\u003EThe project guides the rapid development of better vaccines to fight emerging infections and improve monitoring for poor responses in the elderly, infants, and those with weakened immune systems.\u003C\/p\u003E\u003Cp\u003EImportantly, the project\u2019s work is expected to help design a universal flu vaccine.\u003C\/p\u003E\u003Cp\u003EThe other four finalists for the 2015 Wagner Prize were:\u003C\/p\u003E\u003Cul\u003E\u003Cli\u003E\u003Cstrong\u003EIntegrated Planning of Multi-type Locomotive Service Facilities under Location, Routing and Inventory Considerations\u003C\/strong\u003E by Kamalesh Somani, Jing Huang, CSX Transportation; Xi Chen, Yanfeng Ouyang, Zhaodong Wang, and Siyang Xie, University of Illinois at Urbana-Champaign\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003EScheduling Crash Tests at Ford Motor Company \u003C\/strong\u003EbyDaniel Reich, Ellen Barnes, Erica Klampfl, Ford Motor Company; Marina Epelman, Amy Cohn, and Yuhui Shi, University of Michigan\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003EStrategic Re-design of Urban Mail and Parcel Networks at La Poste \u003C\/strong\u003Eby Stefan Spinler, WHU-Otto Beisheim School of Management; Matthias Winkenbach, Massachusetts Institute of Technology; and Alain Roset, La Poste\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003EUsing Analytics to Enhance Shelf Space Management in a Food Retailer\u003C\/strong\u003E by Teresa Bianchi de Aguiar, Maria Ant\u00f3nia Carravilla, Luis Guimar\u00e3es, Jos\u00e9 Oliveira, and Elsa Silva, University of Porto; Jorge Liz, Jo\u00e3o G\u00fcnther Amaral, and S\u00e9rgio Lapela, Sonae MC\u003C\/li\u003E\u003C\/ul\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A team of researchers from three institutions were awarded the prestigious INFORMS Daniel H. Wagner Prize for their work."}],"uid":"28766","created_gmt":"2015-11-04 14:40:16","changed_gmt":"2016-10-08 03:19:54","author":"Shelley Wunder-Smith","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2015-11-04T00:00:00-05:00","iso_date":"2015-11-04T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"466211":{"id":"466211","type":"image","title":"Eva K. Lee","body":null,"created":"1449256408","gmt_created":"2015-12-04 19:13:28","changed":"1475895213","gmt_changed":"2016-10-08 02:53:33","alt":"Eva K. Lee","file":{"fid":"203752","name":"eva_lee_2006.jpg","image_path":"\/sites\/default\/files\/images\/eva_lee_2006_0.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/eva_lee_2006_0.jpg","mime":"image\/jpeg","size":227701,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/eva_lee_2006_0.jpg?itok=JK9P0HLV"}}},"media_ids":["466211"],"groups":[{"id":"1242","name":"School of Industrial and Systems Engineering (ISYE)"}],"categories":[{"id":"134","name":"Student and Faculty"}],"keywords":[{"id":"276","name":"Awards"},{"id":"123","name":"CDC"},{"id":"2305","name":"Emory University"},{"id":"9238","name":"Eva K. Lee"},{"id":"763","name":"vaccine"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShelley Wunder-Smith\u003C\/p\u003E\u003Cp\u003EStewart School of Industrial \u0026amp; Systems Engineering\u003C\/p\u003E\u003Cp\u003E404.385.4745\u003C\/p\u003E","format":"limited_html"}],"email":["shelley.wunder-smith@isye.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}