{"50231":{"#nid":"50231","#data":{"type":"news","title":"Magnetic Nanoparticles Show Promise for Combating Human Cancer","body":[{"value":"\u003Cp\u003EScientists at Georgia Tech and\nthe Ovarian Cancer Institute have further developed a potential new treatment\nagainst cancer that uses magnetic nanoparticles to attach to cancer cells,\nremoving them from the body. The treatment, tested in mice in 2008, has now\nbeen tested using samples from human cancer patients. The results appear online\nin the journal \u003Cem\u003ENanomedicine\u003C\/em\u003E.\u003C\/p\u003E\n\n\u003Cp\u003E\u201cWe are primarily interested in developing an effective\nmethod to reduce the spread of ovarian cancer cells to other organs ,\u201d said\nJohn McDonald, professor at the the School of Biology at the Georgia Institute\nof Technology and chief research scientist at the Ovarian Cancer Institute.\u003C\/p\u003E\n\n\u003Cp\u003E\u0026nbsp;The idea came to the research team from the work of Ken\nScarberry, then a Ph.D. student at Tech. Scarberry originally conceived of the\nidea as a means of extracting viruses and virally infected cells. At his\nadvisor\u2019s suggestion Scarberry began looking at how the system could work with\ncancer cells.\u003C\/p\u003E\n\n\u003Cp\u003E\u0026nbsp;He published his first paper on the subject in the \u003Cem\u003EJournal\nof the American Chemical Society\u003C\/em\u003E in July 2008. In that paper he and\nMcDonald showed that by giving the cancer cells of the mice a fluorescent green\ntag and staining the magnetic nanoparticles red, they were able to apply a\nmagnet and move the green cancer cells to the abdominal region.\u003C\/p\u003E\n\n\u003Cp\u003E\u0026nbsp;Now McDonald and Scarberry, currently a post-doc in McDonald\u2019s\nlab, has showed that the magnetic technique works with human cancer cells.\u003C\/p\u003E\n\n\u003Cp\u003E\u0026nbsp;\u201cOften, the lethality of cancers\nis not attributed to the original tumor but to the establishment of distant\ntumors by cancer cells that exfoliate from the primary tumor,\u201d said Scarberry.\n\u201cCirculating tumor cells can implant at distant sites and give rise to\nsecondary tumors.\u0026nbsp; Our technique is\ndesigned to filter the peritoneal fluid or blood and remove these free floating\ncancer cells, which should increase longevity by preventing the continued\nmetastatic spread of the cancer.\u201d\u003C\/p\u003E\n\n\u003Cp\u003E\u0026nbsp;In tests, they showed that their\ntechnique worked as well with at capturing cancer cells from human patient\nsamples as it did previously in mice. The next step is to test how well the\ntechnique can increase survivorship in live animal models. If that goes well,\nthey will then test it with humans.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Scientists at Georgia Tech and the Ovarian Cancer Institute have further developed a potential new treatment against cancer that uses magnetic nanoparticles to attach to cancer cells, removing them from the body. The treatment, tested in mice in 2008, has now been tested using samples from human cancer patients.","format":"limited_html"}],"field_summary_sentence":[{"value":"Scientists show how magnetic nanoparticles can fight cancer"}],"uid":"27310","created_gmt":"2010-01-28 09:08:48","changed_gmt":"2016-10-08 03:04:12","author":"David Terraso","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2010-02-01T00:00:00-05:00","iso_date":"2010-02-01T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"50232":{"id":"50232","type":"image","title":"Magnetic Nanoparticles Attach to Human Cancer Cells","body":null,"created":"1449175437","gmt_created":"2015-12-03 20:43:57","changed":"1475894471","gmt_changed":"2016-10-08 02:41:11","alt":"Magnetic Nanoparticles Attach to Human Cancer Cells","file":{"fid":"190151","name":"CAPTURED_ASCITES_CELLS_BRIGHT_FIELD_40X.jpg","image_path":"\/sites\/default\/files\/images\/CAPTURED_ASCITES_CELLS_BRIGHT_FIELD_40X.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/CAPTURED_ASCITES_CELLS_BRIGHT_FIELD_40X.jpg","mime":"image\/jpeg","size":779583,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/CAPTURED_ASCITES_CELLS_BRIGHT_FIELD_40X.jpg?itok=OEKbn4p8"}}},"media_ids":["50232"],"groups":[{"id":"1183","name":"Home"}],"categories":[{"id":"140","name":"Cancer Research"},{"id":"146","name":"Life Sciences and Biology"}],"keywords":[{"id":"385","name":"cancer"},{"id":"2053","name":"magnetic"},{"id":"382","name":"nanoscience"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EDavid Terraso\u003C\/p\u003E\u003Cp\u003ECommunications and Marketing\u003C\/p\u003E\u003Cp\u003E404-385-2966\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022mailto:david.terraso@comm.gatech.edu\u0022\u003Edavid.terraso@comm.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}