{"512821":{"#nid":"512821","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Engineering Effector Proteins as Modulators of Cell Signaling Pathways for Breast Cancer Therapy\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJulie A. Champion, Ph.D.\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssistant Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ETanner Junior Faculty Fellow\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Chemical \u0026amp; Biomolecular Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Tech\u003C\/strong\u003E\u003Cbr \/\u003E \u003Cbr \/\u003EAbstract\u003Cbr \/\u003EBacterial pathogens trigger cell death by a variety of mechanisms, including injection of effector proteins. Effector proteins have great potential as anti-cancer agents because they efficiently subvert a variety of eukaryotic signaling pathways involved in cancer development, drug resistance, and metastasis. In this talk, I will discuss our use of YopJ, an effector from Yersinia pestis, as a potential breast cancer therapeutic. In breast cancer, MAPK and NF\u03baB pathways are known to be dysregulated. YopJ down-regulates MAPK and NF\u03baB pathways to induce cell death in specific cell types and we seek to exploit this infection-enabling protein for therapeutic use. We engineered YopJ to self-assemble into protein nanoparticles to efficiently deliver protein to cells, replacing the need for the pathogen secretion mechanism for effector delivery to host cells. YopJ nanoparticles induced dose and time-dependent death in multiple breast cancer cell lines. Treatment with sub-lethal doses of nanoparticles was still seen to be beneficial as well, decreasing metastasis-related behaviors and MAPK signaling. YopJ nanoparticles demonstrate the potential of engineered effector proteins as breast cancer therapeutics.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u0022Engineering Effector Proteins as Modulators of Cell Signaling Pathways for Breast Cancer Therapy\u0022 - Julie Champion, Ph.D. - Georgia Tech"}],"uid":"27195","created_gmt":"2016-03-14 08:56:22","changed_gmt":"2017-04-13 21:16:20","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-03-15T17:00:00-04:00","event_time_end":"2016-03-15T18:00:00-04:00","event_time_end_last":"2016-03-15T18:00:00-04:00","gmt_time_start":"2016-03-15 21:00:00","gmt_time_end":"2016-03-15 22:00:00","gmt_time_end_last":"2016-03-15 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"361991":{"id":"361991","type":"image","title":"Integrated Cancer Research Center","body":null,"created":"1449245782","gmt_created":"2015-12-04 16:16:22","changed":"1475895098","gmt_changed":"2016-10-08 02:51:38","alt":"Integrated Cancer Research Center","file":{"fid":"201581","name":"icrc_logo_image_2014-square.jpg","image_path":"\/sites\/default\/files\/images\/icrc_logo_image_2014-square_0.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/icrc_logo_image_2014-square_0.jpg","mime":"image\/jpeg","size":3173213,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/icrc_logo_image_2014-square_0.jpg?itok=0Vt6IfQ_"}}},"media_ids":["361991"],"related_links":[{"url":"http:\/\/icrc.gatech.edu\/","title":"Integrated Cancer Research Center website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, Ph.D. \u003C\/a\u003E- faculty host\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}