{"541611":{"#nid":"541611","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u0022Novel Approaches for\u0026nbsp;Detecting and Treating Retinal Disease\u0022\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMachelle Pardue, Ph.D.\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EProfessor\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EWallace H. Coulter Department of Biomedical Engineering\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EGeorgia Tech\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E\u003Cem\u003ERESEARCH\u003Cbr \/\u003E\u003C\/em\u003E\u003Cstrong\u003ENeuroprotective treatments\u003Cbr \/\u003E\u003C\/strong\u003EOriginating with biocompatibility studies with a subretinal prosthetic, Machelle Pardue has been investigating the neuroprotective effects of subretinal electrical stimulation (SES) on the retina using electrophysiological, histological, and molecular techniques. This work has shown that low level electrical current preserves photoreceptor function and structure. This preservation is associated with the selective and sustained upregulation of fibroblast growth factor beta (FGF2). Currently, her laboratory is exploring cellular and molecular mechanisms of this neuroprotective response as well as determining which retinal diseases benefit from SES.\u003C\/p\u003E\u003Cp\u003EHer laboratory also has been involved in testing other neuroprotective agents with anti-apoptotic properties, such as the bile acid, tauroursodeoxycholic acid (TUDCA), and other proprietary formulas. These studies are designed to develop neuroprotective treatments for retinal degenerative diseases that could slow the progression of vision loss.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ERetinal mechanisms of refractive development\u003C\/strong\u003E \u003Cbr \/\u003ECombining her knowledge of the retina, transgenic mouse models, and optical aspects of the eye, Pardue is investigating how retinal defocus is detected by the retina and translated into a signaling pathway that drives refractive development. By exploiting transgenic mouse models, the influence of specific retinal cells and pathways can be isolated to determine refractive development, particularly myopia, under normal and abnormal visual conditions. This work is aimed at furthering our knowledge of basic retinal physiology, refractive development and refractive errors.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDiabetic retinopathy\u003C\/strong\u003E \u003Cbr \/\u003EDiabetic retinopathy, one of leading causes of vision loss, is currently only detected in late stages of the disease. Pardue\u2019s research on diabetic retinopathy is focused on finding non-invasive predictive markers of this disease. Her laboratory is combining information from electrophysiological, imaging, immunohistochemical, and molecular techniques to build a complete understanding of the pathophysiology of neuronal and vascular changes with diabetic retinopathy. These studies focus on following diabetic animal models longitudinally to reveal changes that predict vision loss. With this knowledge, predictive, non-invasive imaging and electrophysiologic changes will be further examined and translated to clinical studies. The goal is to detect diabetic retinopathy before vision loss occurs, thus providing an opportunity for increased glycemic control and\/or other pharmacological treatments.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Novel Approaches for Detecting and Treating Retinal Disease\u0022 - Machelle Pardue, Ph.D. - Georgia Tech"}],"uid":"27195","created_gmt":"2016-06-02 14:01:56","changed_gmt":"2017-04-13 21:15:40","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-13T09:30:00-04:00","event_time_end":"2016-09-13T10:30:00-04:00","event_time_end_last":"2016-09-13T10:30:00-04:00","gmt_time_start":"2016-09-13 13:30:00","gmt_time_end":"2016-09-13 14:30:00","gmt_time_end_last":"2016-09-13 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"https:\/\/bme.gatech.edu\/bme\/faculty\/Machelle-Pardue","title":"Pardue profile"},{"url":"http:\/\/petitinstitute.gatech.edu\/breakfast-club","title":"Breakfast Club Seminar schedule"}],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"1808","name":"graduate students"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003Cbr \/\u003EEvents Manager\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}