{"558931":{"#nid":"558931","#data":{"type":"event","title":"Sam Brown, Georgia Insitiute of Technology","body":[{"value":"\u003Cp\u003EBack to the Future: Making Old Antibiotics Work Again\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EIn my job talk a year ago I asked \u2018can we make evolution-proof drugs?\u2019, and offered theory and experimental evidence that this is possible. I showed that by targeting bacterial collective traits (eg. extracellular digestion) we can make drugs that select against resistance mutations. In this talk I will pick up on the problem I spelt out at the end of my job talk - our candidate \u2018evolution proof\u2019 treatments are sadly not the most effective drugs - and outline solutions that aim to restore and maintain the efficacy of our most potent drugs, our fading arsenal of old antibiotics. I will outline three overlapping strategies that we are currently developing - defusing resistance with adjuvants, killing resistant cells with phages and conditioning treatment choices on rapid and specific resistance diagnoses. In principle, these strategies offer a route to effective and evolutionarily robust treatments.\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Sam Brown, Georgia Insitiute of Technology"}],"uid":"27964","created_gmt":"2016-08-03 12:59:40","changed_gmt":"2017-04-13 21:15:14","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-08T12:00:00-04:00","event_time_end":"2016-09-08T12:00:00-04:00","event_time_end_last":"2016-09-08T12:00:00-04:00","gmt_time_start":"2016-09-08 16:00:00","gmt_time_end":"2016-09-08 16:00:00","gmt_time_end_last":"2016-09-08 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"167225","name":"Sam Brown"},{"id":"166892","name":"School of Biological Sciences Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EIf you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology\u0027s administrative office at \u003Ca href=\u0022mailto:bio-admin@biology.gatech.edu\u0022\u003Ebio-admin@biology.gatech.edu\u003C\/a\u003E.\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}