{"566911":{"#nid":"566911","#data":{"type":"event","title":"The ruggedness of adaptive fitness landscape and the reproducibility of RNA virus evolution","body":[{"value":"\u003Cp\u003ESantiago Elena, Polytechnical University of Valencia \u0026amp; The Santa Fe Institute\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAbstract:\u003Cbr \/\u003E RNA viruses are the main source of emerging infectious diseases given the \u003Cbr \/\u003E evolutionary potential bestowed by their fast replication, large population \u003Cbr \/\u003E sizes and high mutation and recombination rates.\u0026nbsp; However, an equally important \u003Cbr \/\u003E parameter, which is usually neglected, is the topography of the fitness \u003Cbr \/\u003E landscape, that is, how many fitness maxima exist and how well connected they \u003Cbr \/\u003E are, which determines the number of accessible evolutionary pathways.\u0026nbsp; In this \u003Cbr \/\u003E talk I will present our efforts to reconstruct and analyze the fitness \u003Cbr \/\u003E landscape describing the adaptation of tobacco etch Potyvirus (TEV) to its new \u003Cbr \/\u003E host, Arabidopsis thaliana ecotype Ler-0.\u0026nbsp; In doing so, I will show how rugged \u003Cbr \/\u003E and holey landscapes enabled evolving TEV lineages to avoid getting trapped in \u003Cbr \/\u003E local optima and, instead, to explore distant regions of the landscape.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003EHost: Joshua Weitz\u003Cbr \/\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"The ruggedness of adaptive fitness landscape and the reproducibility of RNA virus evolution"}],"uid":"27964","created_gmt":"2016-08-23 14:38:49","changed_gmt":"2017-04-13 21:15:00","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-01T16:00:00-04:00","event_time_end":"2016-09-01T16:00:00-04:00","event_time_end_last":"2016-09-01T16:00:00-04:00","gmt_time_start":"2016-09-01 20:00:00","gmt_time_end":"2016-09-01 20:00:00","gmt_time_end_last":"2016-09-01 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"11599","name":"Joshua Weitz"},{"id":"168750","name":"Santiago F. Elena"},{"id":"166892","name":"School of Biological Sciences Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}