{"587156":{"#nid":"587156","#data":{"type":"event","title":"Quantitative Predictions in a Drosophila Visuomotor Network","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAnmo Kim, The Rockefeller University\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003E\u003Cbr \/\u003E\r\nVision influences behavior,\u0026nbsp;but ongoing behavior also modulates vision, from insects to primates.\u0026nbsp;For example, we constantly move our eyes\u0026nbsp;from one point to\u0026nbsp;another, even as we view a static scene. These eye movements\u0026nbsp;cause the whole visual image to shift on our retinas; yet we hardly notice they\u0026nbsp;are happening. The same\u0026nbsp;visual motion, if replayed, causes a strong sense of\u0026nbsp;visual motion. Consistent with this behavioral observation, previous studies\u0026nbsp;reported transient modulation of visual\u0026nbsp;processing during rapid eye movements. However,\u0026nbsp;the function and biophysical mechanisms of most such\u0026nbsp;modulations remain unresolved. We investigated a function for\u0026nbsp;behavioral\u0026nbsp;modulations of visual processing in\u0026nbsp;\u003Cem\u003EDrosophila\u003C\/em\u003E\u0026nbsp;by combining behavioral genetics, electrophysiology, and high-speed\u0026nbsp;videography. We provide evidence that,\u0026nbsp;via a genetic inactivation experiments, a\u0026nbsp;set of motion-sensitive visual neurons regulate gaze-stabilizing head\u0026nbsp;movements. We describe how, during flight turns,\u0026nbsp;\u003Cem\u003EDrosophila\u003C\/em\u003E\u0026nbsp;perform a set of head movements that require silencing\u0026nbsp;their gaze-stability reflexes along the primary rotation axis of the turn.\u0026nbsp;Consistent with this behavioral\u0026nbsp;requirement, we find pervasive motor-related\u0026nbsp;inputs to the visual neurons, which quantitatively silence their predicted visual\u0026nbsp;responses to rotations around the relevant\u0026nbsp;axis while preserving sensitivity\u0026nbsp;around other axes. This work proposes a function for a behavioral modulation of\u0026nbsp;visual processing and illustrates how the brain can\u0026nbsp;remove one sensory signal\u0026nbsp;from a circuit carrying multiple related signals.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAnmo Kim, The Rockefeller University\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003E\u003Cbr \/\u003E\r\nVision influences behavior,\u0026nbsp;but ongoing behavior also modulates vision, from insects to primates.\u0026nbsp;For example, we constantly move our eyes\u0026nbsp;from one point to\u0026nbsp;another, even as we view a static scene. These eye movements\u0026nbsp;cause the whole visual image to shift on our retinas; yet we hardly notice they\u0026nbsp;are happening. The same\u0026nbsp;visual motion, if replayed, causes a strong sense of\u0026nbsp;visual motion. Consistent with this behavioral observation, previous studies\u0026nbsp;reported transient modulation of visual\u0026nbsp;processing during rapid eye movements. However,\u0026nbsp;the function and biophysical mechanisms of most such\u0026nbsp;modulations remain unresolved. We investigated a function for\u0026nbsp;behavioral\u0026nbsp;modulations of visual processing in\u0026nbsp;\u003Cem\u003EDrosophila\u003C\/em\u003E\u0026nbsp;by combining behavioral genetics, electrophysiology, and high-speed\u0026nbsp;videography. We provide evidence that,\u0026nbsp;via a genetic inactivation experiments, a\u0026nbsp;set of motion-sensitive visual neurons regulate gaze-stabilizing head\u0026nbsp;movements. We describe how, during flight turns,\u0026nbsp;\u003Cem\u003EDrosophila\u003C\/em\u003E\u0026nbsp;perform a set of head movements that require silencing\u0026nbsp;their gaze-stability reflexes along the primary rotation axis of the turn.\u0026nbsp;Consistent with this behavioral\u0026nbsp;requirement, we find pervasive motor-related\u0026nbsp;inputs to the visual neurons, which quantitatively silence their predicted visual\u0026nbsp;responses to rotations around the relevant\u0026nbsp;axis while preserving sensitivity\u0026nbsp;around other axes. This work proposes a function for a behavioral modulation of\u0026nbsp;visual processing and illustrates how the brain can\u0026nbsp;remove one sensory signal\u0026nbsp;from a circuit carrying multiple related signals.\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Anmo Kim, The Rockefeller University"}],"uid":"27964","created_gmt":"2017-02-08 17:27:46","changed_gmt":"2017-04-13 21:12:56","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-02-17T11:00:00-05:00","event_time_end":"2017-02-17T12:00:00-05:00","event_time_end_last":"2017-02-17T12:00:00-05:00","gmt_time_start":"2017-02-17 16:00:00","gmt_time_end":"2017-02-17 17:00:00","gmt_time_end_last":"2017-02-17 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"4896","name":"College of Sciences"},{"id":"166892","name":"School of Biological Sciences Seminar"},{"id":"76431","name":"Georgia Tech Neuro"},{"id":"25121","name":"gt neuro"},{"id":"17641","name":"gtneuro"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EIf you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biological Sciences\u0026#39; administrative office at \u003Ca href=\u0022mailto:bio-admin@biology.gatech.edu\u0022\u003Ebio-admin@lists.gatech.edu\u003C\/a\u003E.\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}