{"589325":{"#nid":"589325","#data":{"type":"event","title":"PhD Proposal by Sunny Hyea Hwang","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ETHE SCHOOL OF MATERIALS SCIENCE AND ENGINEERING\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EGEORGIA INSTITUTE OF TECHNOLOGY\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EUnder the provisions of the regulations for the degree\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDOCTOR OF PHILOSOPHY\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003Eon Wednesday, April 6, 2017\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E1:00 PM\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003Ein MRDC 4404\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003Ewill be held the\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDISSERTATION PROPOSAL DEFENSE\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003Efor\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ESunny Hyea Hwang\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026quot;Elucidation of the coupling between mechanical and biophysical properties of biological membranes\u0026quot;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EProf. James C. Gumbart, Advisor, PHYS\u003Cbr \/\u003E\r\nProf. Karl Jacob, Co-advisor, MSE\u003Cbr \/\u003E\r\nProf. Hamid Garmestani,\u0026nbsp; MSE\u003Cbr \/\u003E\r\nProf. Donggang Yao, MSE\u003Cbr \/\u003E\r\nProf. Peter Yunker, PHYS\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe membranes of practically all living organisms and many viruses are made of a semipermeable lipid bilayer, which is composed of two layers of fatty acids, often containing many embedded proteins. This bilayer, a self-assembled soft material, can take on a multitude of shapes and sizes depending on its composition and its environment.\u0026nbsp; It is responsible for maintaining the boundary of a cell, distinguishing inside from outside, and for selectively mediating the permeability of molecules across it.\u0026nbsp; Quantifying the diverse functionality of membranes requires elucidating their mechanical properties and how those properties depend on their constituents.\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nThe bacterial cell envelope presents an especially complex example of membrane structure.\u0026nbsp; It is a multilayered structure that serves to protect these organisms from their unpredictable and often hostile environment. The cell envelope in Gram-negative bacteria is made of two distinct membranes and a cell wall (covalently connected mesh-like elastic network of sugars and peptides) between them. Although there is growing interest in the mechanical adaptation of this cell envelope to the high turgor pressure emanating from within, how the cell wall, inner membrane (IM), and outer membrane (OM) couple together to provide this adaption remains unexplored. Therefore, the first part of the proposed research is to determine how much osmotic stress each bacterial membrane can withstand and how that stress is communicated to the cell wall. In this study, we will use molecular dynamics (MD) simulations, which provides molecular-level insight into these complex systems that is difficult to obtain by experimental studies alone. Simulations of individual membranes at different protein concentrations as well as membranes coupled to the cell wall will be carried out. In order to describe the membranes\u0026rsquo; elasticity, we will focus on the low-tension (elastic) regime, which can be exploited to measure the area compressibility modulus and Young\u0026rsquo;s modulus. The high-tension, non-linear regime will also be studied for the cell wall to test the hypothesis that it will exhibit stress stiffening.\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nThe second part of the proposed research will involve an estimation of small-molecule permeation through membranes, which is of critical importance for the delivery of candidate drugs to an intracellular target. Passive permeation of drugs through cell membranes is strongly dependent on the molecule\u0026#39;s physico-chemical properties.\u0026nbsp; In this study, we will describe a new approach using the deformation free energy of a lipid bilayer based on the principle of a continuum theory. To gain atomistic insight into the passive permeability process, we will use physics-based methods and MD simulation, combined with the inhomogeneous solubility-diffusion model. The estimated permeability from our method will be compared with other popular method such as Quantitative Structure-Property Relationship (QSAR) analysis.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u0022Elucidation of the coupling between mechanical and biophysical properties of biological membranes"}],"uid":"27707","created_gmt":"2017-03-27 17:21:35","changed_gmt":"2017-03-27 17:21:35","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-04-06T14:00:00-04:00","event_time_end":"2017-04-06T16:00:00-04:00","event_time_end_last":"2017-04-06T16:00:00-04:00","gmt_time_start":"2017-04-06 18:00:00","gmt_time_end":"2017-04-06 20:00:00","gmt_time_end_last":"2017-04-06 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}