{"604140":{"#nid":"604140","#data":{"type":"event","title":"CSE Distinguished Lecture: Orly Alter","body":[{"value":"\u003Cdiv\u003E\r\n\u003Cp\u003E\u003Cstrong\u003ESpeaker: Orly Alter\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EUSTAR\u0026nbsp;Associate Professor of Bioengineering and Human Genetics,\u003C\/p\u003E\r\n\r\n\u003Cp\u003EScientific Computing and Imaging Institute, Huntsman Cancer Institute\u003C\/p\u003E\r\n\r\n\u003Cp\u003EUniversity of Utah\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThursday, March 29, 2018\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u0026nbsp;\u0026nbsp;\u003C\/strong\u003EKlaus Advanced Computing Building, Room 1116E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u0026nbsp;\u003C\/strong\u003E11:00am \u0026ndash; 12:00pm\u003C\/p\u003E\r\n\r\n\u003Cp\u003E------------------------------ -----\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EComparative Spectral Decompositions for Personalized Cancer Diagnostics, Prognostics, and Therapeutics\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EI will describe the development of novel, multi-tensor generalizations of the singular value decomposition, and their use in the comparisons of brain, lung, ovarian, and uterine cancer and normal genomes, to\u0026nbsp;uncover patterns of DNA copy-number alterations that predict survival and response to treatment, statistically better than, and independent of, the best indicators in clinical use and existing laboratory tests.\u0026nbsp;Recurring alterations have been recognized as a hallmark of cancer for over a century, and observed in these cancers\u0026rsquo; genomes for decades; however, copy-number subtypes predictive of patients\u0026rsquo; outcomes were\u0026nbsp;not identified before. The data had been publicly available, but the patterns remained unknown until the data were modeled by using the multi-tensor decompositions, illustrating the universal ability of these\u0026nbsp;decompositions \u0026ndash; generalizations of the frameworks that underlie the theoretical description of the physical world \u0026ndash; to find what other methods miss.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBio:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOrly Alter is a USTAR associate professor of bioengineering and human genetics at the Scientific Computing and Imaging Institute and the Huntsman Cancer Institute at the University of Utah, and the principal\u0026nbsp;investigator of an NCI Physical Sciences in Oncology U01 project grant. Inventor of the \u0026ldquo;eigengene,\u0026rdquo; she pioneered the matrix and tensor modeling of large-scale molecular biological data, which, as she\u0026nbsp;demonstrated, can be used to correctly predict previously unknown physical, cellular and evolutionary mechanisms. Alter received her Ph.D. in applied physics at Stanford University, and her B.Sc.\u0026nbsp;\u003Cem\u003Emagna cum\u0026nbsp;laude\u003C\/em\u003E\u0026nbsp;in physics at Tel Aviv University. Her Ph.D. thesis on \u0026ldquo;Quantum Measurement of a Single System,\u0026rdquo; which was published by Wiley-Interscience as a book, is recognized today as crucial to the field of\u0026nbsp;gravitational wave detection.\u003C\/p\u003E\r\n\u003C\/div\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"CSE Distinguished Lecture: Orly Alter"}],"uid":"28150","created_gmt":"2018-03-22 17:42:54","changed_gmt":"2018-03-22 17:42:54","author":"Birney Robert","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-03-29T12:00:00-04:00","event_time_end":"2018-03-29T13:00:00-04:00","event_time_end_last":"2018-03-29T13:00:00-04:00","gmt_time_start":"2018-03-29 16:00:00","gmt_time_end":"2018-03-29 17:00:00","gmt_time_end_last":"2018-03-29 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"604138":{"id":"604138","type":"image","title":"Orly Alter","body":null,"created":"1521740077","gmt_created":"2018-03-22 17:34:37","changed":"1521740077","gmt_changed":"2018-03-22 17:34:37","alt":"","file":{"fid":"230288","name":"Unknown.png","image_path":"\/sites\/default\/files\/images\/Unknown_3.png","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Unknown_3.png","mime":"image\/png","size":5527549,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Unknown_3.png?itok=2ZoakvLw"}}},"media_ids":["604138"],"groups":[{"id":"47223","name":"College of Computing"},{"id":"50877","name":"School of Computational Science and Engineering"}],"categories":[],"keywords":[{"id":"177508","name":"Orly Alter"},{"id":"177509","name":"CSE Distinguished"},{"id":"654","name":"College of Computing"},{"id":"109","name":"Georgia Tech"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EKristen Perez\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ekristen.perez@cc.gatech.edu\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}