{"61421":{"#nid":"61421","#data":{"type":"news","title":"NIH Awards $14.6M Translational Cardiovascular Nanomedicine Center","body":[{"value":"\u003Cp\u003EGeorgia Tech and Emory University have received a five-year $14.6 million contract from the National Institutes of Health (NIH) to continue the development of nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis. \u003C\/p\u003E\n\u003Cp\u003EAtherosclerosis typically occurs in branched or curved regions of arteries where plaques form because of cholesterol build-up. Inflammation can alter the structure of plaques so they become more likely to rupture, potentially causing a blood vessel blockage and leading to heart attack or stroke.\n\u003C\/p\u003E\n\u003Cp\u003EThe award will support the interdisciplinary Center for Translational Cardiovascular Nanomedicine as the second phase of the Program of Excellence in Nanotechnology (PEN), originally established in 2005 with funding from the National Heart, Lung, and Blood Institute of the NIH. This Center integrates the biomedical engineering expertise of Georgia Tech and the cardiology strengths of Emory University\u0027s School of Medicine. The broad and long-term goal of the PEN is to improve the diagnosis and treatment of cardiovascular disease, which is the leading cause of death for men and women in the United States. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022In the last five years, we developed a suite of nanotechnology approaches for diagnosing and treating cardiovascular disease and we have demonstrated their efficacy in terms of potential clinical application,\u0022 said Gang Bao, the program\u0027s director and the Robert A. Milton Chair in Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. \u0022For the next five years, we will focus on translating these technologies into clinical utility and we would like to have some of these nanotechnologies ready for human clinical trials by the end of this five-year period.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EDuring the first five years of the PEN, the Georgia Tech and Emory University researchers have made contributions in nanotechnology development, basic cardiology research and inflammatory biomarker detection. The research team has published or submitted more than 80 peer-reviewed papers, filed nine patents and established three startup companies to commercialize the nanotechnologies. \n\u003C\/p\u003E\n\u003Cp\u003E\u0027There is a great unmet need to develop innovative diagnostic modalities that inform the activity of the inflammatory disease and to guide evaluation of therapy,\u0022 explained Bao, who is also a Georgia Tech College of Engineering Distinguished Professor. \u0022Our nanotechnology toolbox will allow us to translate more mature nanotechnologies to clinical utility and evaluate new nanotechnologies that will provide unique functionalities and novel applications.\u0022   \n\u003C\/p\u003E\n\u003Cp\u003EThe second phase of the PEN will build on the foundation developed and progress made during the last five years to accomplish four goals:\n\u003C\/p\u003E\n\u003Cp\u003E\u2022 Using nanoparticle probes to image and characterize atherosclerotic plaques\u003Cbr \/\u003E\n\u2022 Diagnosing cardiovascular disease from a blood sample\u003Cbr \/\u003E\n\u2022 Designing new methods for delivering anti-atherosclerosis drugs and genes into the body\u003Cbr \/\u003E\n\u2022 Developing stem cell based therapies to repair damaged heart tissue\n\u003C\/p\u003E\n\u003Cp\u003EThe researchers will use the suite of nanotechnologies they developed in the last five years -- including molecular beacons, magnetic nanoparticles, gold nanoparticles, quantum dots, polyketals and hydrocyanine dyes -- to accomplish these goals. \n\u003C\/p\u003E\n\u003Cp\u003EThe first goal focuses on determining if an individual\u0027s atherosclerotic plaque will grow and rupture. Having this information would allow physicians to treat atherosclerosis more effectively.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022By using nanoparticle probes \u003Cem\u003Ein vitro\u003C\/em\u003E and \u003Cem\u003Ein vivo\u003C\/em\u003E, we hope to be able to detect early-stage cardiovascular disease,\u0022 noted Bao, \u0022but many important issues such as detection specificity, toxicity and safety still need to be addressed.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EIn addition to \u003Cem\u003Ein vivo\u003C\/em\u003E imaging of plaques using magnetic resonance imaging (MRI) and positron emission tomography (PET), the research team is developing a laboratory diagnostic test for detecting cardiovascular disease from a blood sample. The presence or levels of specific micro-RNAs, reactive oxygen species or protein markers in the blood will be tested as an indication of the presence and stage of atherosclerosis. This diagnostic approach has the advantages of being fast, inexpensive and nontoxic. \n\u003C\/p\u003E\n\u003Cp\u003EOnce atherosclerosis is detected in an individual, it needs to be treated. Several small molecule drugs have been identified as potent therapeutic agents for cardiovascular diseases, but their clinical utility is limited due to their water-repellant nature and short circulation half-life. A novel approach for targeted drug or gene delivery is to use nanoparticles to carry the small molecules into the body. This type of delivery system has the advantage of combining targeting, imaging and controlled release, and can be tailored to optimize circulation time and reduce toxicity. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022Delivering these small molecules in a specific, sufficient and sustained manner to localized vascular lesions may significantly improve the clinical outcomes of cardiovascular diseases,\u0022 said Bao.\n\u003C\/p\u003E\n\u003Cp\u003EFor the final goal, the research team will use stem cells to create a personalized treatment strategy for repairing damage caused by atherosclerosis. The researchers plan to use nanotechnologies to generate and deliver patient-specific induced pluripotent stem cells to the injured vasculature and heart to repair the damage.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Our goals are ambitious as we plan to further develop our nanoscale tools and nanocardiology knowledge base, to translate the new tools and nanotechnologies to clinical applications in diagnosing and treating cardiovascular disease, and to train the next generation of leaders in cardiovascular nanomedicine,\u0022 added Bao.\n\u003C\/p\u003E\n\u003Cp\u003EAlso contributing from the Coulter Department are professors Don Giddens, Xiaoping Hu, Hanjoong Jo, Shuming Nie, and W. Robert Taylor; associate professors Niren Murthy and May Dongmei Wang; and assistant professor Michael Davis. Giddens is also dean of Georgia Tech\u0027s College of Engineering. Taylor is also the director of Emory\u2019s Division of Cardiology and a member of the Atlanta VA Medical Center\u2019s Division of Cardiology.\n\u003C\/p\u003E\n\u003Cp\u003EContributors from Emory University include Department of Medicine chair Wayne Alexander; Division of Cardiology professors David Harrison and Kathy Griendling, associate professor Young-sup Yoon and assistant professor Charles Searles Jr.; and Department of Radiology professor Mark Goodman. Katherine Ferrara, a biomedical engineering professor at the University of California, Davis, is also collaborating on the project.\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EResearch News \u0026amp; Publications Office\u003Cbr \/\u003E\nGeorgia Institute of Technology\u003Cbr \/\u003E\n75 Fifth Street, N.W., Suite 314\u003Cbr \/\u003E\nAtlanta, Georgia  30308  USA\u003C\/strong\u003E\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EMedia Relations Contacts:\u003C\/strong\u003E Abby Vogel Robinson (abby@innovate.gatech.edu; 404-385-3364) or John Toon (jtoon@gatech.edu; 404-894-6986)\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EWriter:\u003C\/strong\u003E Abby Vogel Robinson\u003C\/p\u003E\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":[{"value":"Center aimed at detecting and treating atherosclerosis using nanoscale tools"}],"field_summary":[{"value":"\u003Cp\u003EGeorgia Tech and Emory University have received a five-year $14.6 million contract from NIH to continue the development of nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Georgia Tech \u0026 Emory received 5-year $14.6M contract from NIH."}],"uid":"27206","created_gmt":"2010-10-04 00:00:00","changed_gmt":"2016-10-08 03:07:31","author":"Abby Vogel Robinson","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2010-10-04T00:00:00-04:00","iso_date":"2010-10-04T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"61422":{"id":"61422","type":"image","title":"Gang Bao Biomedical Engineering","body":null,"created":"1449176337","gmt_created":"2015-12-03 20:58:57","changed":"1475894536","gmt_changed":"2016-10-08 02:42:16","alt":"Gang Bao Biomedical Engineering","file":{"fid":"191354","name":"txa10075.jpg","image_path":"\/sites\/default\/files\/images\/txa10075_0.jpg","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/txa10075_0.jpg","mime":"image\/jpeg","size":597562,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/txa10075_0.jpg?itok=s74eKrMB"}}},"media_ids":["61422"],"related_links":[{"url":"http:\/\/www.bme.gatech.edu\/facultystaff\/faculty_record.php?id=2","title":"Gang Bao"},{"url":"http:\/\/www.bme.gatech.edu\/","title":"Wallace H. Coulter Department of Biomedical Engineering"},{"url":"http:\/\/pen.bme.gatech.edu\/","title":"Program of Excellence in Nanotechnology"}],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"149","name":"Nanotechnology and Nanoscience"},{"id":"135","name":"Research"}],"keywords":[{"id":"7270","name":"atherosclerosis"},{"id":"10841","name":"atherosclerosis detection"},{"id":"10842","name":"atherosclerosis treatment"},{"id":"3184","name":"cardiovascular disease"},{"id":"10843","name":"cardiovascular disease diagnosis"},{"id":"3346","name":"drug delivery"},{"id":"10846","name":"gold nanoparticles"},{"id":"250","name":"hydrocyanines"},{"id":"10845","name":"magnetic nanoparticles"},{"id":"3183","name":"molecular beacons"},{"id":"10844","name":"Molecular Biomarkers"},{"id":"10847","name":"nanocardiology"},{"id":"2054","name":"nanoparticle"},{"id":"1449","name":"nanoprobe"},{"id":"107","name":"Nanotechnology"},{"id":"7240","name":"polyketal"},{"id":"2363","name":"quantum dots"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAbby Vogel Robinson\u003C\/strong\u003E\u003Cbr \/\u003EResearch News and Publications\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=avogel6\u0022\u003EContact Abby Vogel Robinson\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-3364\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"email":["abby@innovate.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}