{"616170":{"#nid":"616170","#data":{"type":"event","title":"Visualizing the Spatial Map in the Brain","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EYi Gu, \u003C\/strong\u003E\u003Cstrong\u003EPh.D\u003C\/strong\u003E\u003Cstrong\u003E.\u003Cbr \/\u003E\r\nPrinceton Neuroscience Institute\u003Cbr \/\u003E\r\nPrinceton University\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003Cbr \/\u003E\r\nThe ability of knowing where we are and finding our way during spatial navigation is closely associated with an \u0026ldquo;inner GPS\u0026rdquo; in the brain, the hippocampal-entorhinal circuit. The medial entorhinal cortex (MEC) contains \u0026ldquo;grid cells\u0026rdquo;, which have one of the most mysterious activity patterns in the brain, as their firing fields lie on a triangular lattice when animals navigate in an open arena. These grid cells together may serve as a coordinate system allowing precise positioning during navigation. Here I will present my study on grid cells in understanding the formation of their activity patterns and their roles in path integration. First, combining cellular-resolution two-photon imaging and virtual reality, I revealed a topographical map of grid cells in the mouse MEC according to their firing properties. This map contributes to a foundation for evaluating circuit models of grid cell network and is consistent with continuous attractor models as the mechanism of grid formation. Second, I discovered a novel cell type, \u0026ldquo;cue cell\u0026rdquo;, in the MEC. Cue cells specifically encode landmark information during virtual navigation and are potentially important for correcting errors in grid cell network during path integration. In my future laboratory, I will develop multifaceted research programs to understand the MEC in both health and disease at the circuit and molecular levels.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A Biological Sciences Seminar by Yi Gu, Ph.D."}],"uid":"27964","created_gmt":"2019-01-09 20:22:36","changed_gmt":"2019-01-18 18:51:23","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-01-22T11:00:00-05:00","event_time_end":"2019-01-22T11:00:00-05:00","event_time_end_last":"2019-01-22T11:00:00-05:00","gmt_time_start":"2019-01-22 16:00:00","gmt_time_end":"2019-01-22 16:00:00","gmt_time_end_last":"2019-01-22 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"178551","name":"Scott Moffat"},{"id":"180121","name":"Yi Gu"},{"id":"166892","name":"School of Biological Sciences Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:jasmine.martin@biosci.gatech.edu\u0022\u003EJasmine Martin\u003C\/a\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}