{"616847":{"#nid":"616847","#data":{"type":"event","title":"Feeling for cell function -- Mechanical phenotyping at 1,000 cells\/sec","body":[{"value":"\u003Ch3\u003ESchool of Physics Soft Condensed Matter \u0026amp; Physics of Living Systems Seminar\u003C\/h3\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe mechanical properties of cells have\u0026nbsp;long been heralded as a label-free, inherent marker of biological function in\u0026nbsp;health and disease. Wide-spread utilization has so far been impeded by the lack\u0026nbsp;of a simple and convenient measurement\u0026nbsp;technique with sufficient throughput. To\u0026nbsp;address this need, we have introduced real-time deformability cytometry (RT-DC)\u0026nbsp;for the continuous mechanical single-cell characterization of large populations\u0026nbsp;(\u0026gt; 100,000 cells) with analysis rates\u0026nbsp;up to 1,000 cells\/s, approaching that\u0026nbsp;of conventional fluorescence-based flow cytometers. Using RT-DC we can\u0026nbsp;sensitively detect cytoskeletal alterations, distinguish cell cycle phases,\u0026nbsp;track hematopoietic stem cell differentiation into\u0026nbsp;distinct lineages and\u0026nbsp;characterize cell\u2011populations\u0026nbsp;in whole blood by their mechanical fingerprint. Our results indicate that cell\u0026nbsp;mechanics can define cell function, can be used as an inherent cell marker and\u0026nbsp;could serve as target for novel\u0026nbsp;therapies. Mechanical phenotyping adds a new functional,\u0026nbsp;marker-free dimension to flow cytometry with diverse applications in biology,\u0026nbsp;biotechnology and medicine.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBio\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJochen Guck received his PhD in Physics from the University of\u0026nbsp;Texas at Austin in 2001. After being a junior group leader at the\u0026nbsp;University of Leipzig, Germany, he moved to the Cavendish Laboratory at Cambridge\u0026nbsp;University, UK, as a\u0026nbsp;Lecturer in 2007 and was promoted to Reader in 2009. In 2012 he became Professor of Cellular Machines at the Technische Universit\u0026auml;t Dresden, Germany. As of October last year he is now director at the Max-Planck Institute for the\u0026nbsp;Science of Light and the Max-Planck Center for Physics and Medicine in Erlangen, Germany. His research centers on the investigation of the physical properties of cells and tissues in order to\u0026nbsp;test their biological importance. The ultimate\u0026nbsp;goal is the transfer of findings to medical application. He has authored over 100 peer-reviewed publications\u0026nbsp;and four patents. His work has been recognized by several awards, including the Cozzarelli Award in 2008, the Paterson Prize in\u0026nbsp;2011,\u0026nbsp;and an Alexander-von-Humboldt Professorship in 2012.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Soft Condensed Matter Seminar, Professor Jochen Guck, Max Planck Institute for the Science of Light"}],"uid":"34720","created_gmt":"2019-01-24 18:54:18","changed_gmt":"2019-01-24 19:02:53","author":"tdavis333","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-02-08T11:00:00-05:00","event_time_end":"2019-02-08T12:00:00-05:00","event_time_end_last":"2019-02-08T12:00:00-05:00","gmt_time_start":"2019-02-08 16:00:00","gmt_time_end":"2019-02-08 17:00:00","gmt_time_end_last":"2019-02-08 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"616849":{"id":"616849","type":"image","title":"Jochen Guck","body":null,"created":"1548356484","gmt_created":"2019-01-24 19:01:24","changed":"1548356484","gmt_changed":"2019-01-24 19:01:24","alt":"","file":{"fid":"234774","name":"Jochen Guck.JPG","image_path":"\/sites\/default\/files\/images\/Jochen%20Guck_0.JPG","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Jochen%20Guck_0.JPG","mime":"image\/jpeg","size":26154,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Jochen%20Guck_0.JPG?itok=M3fX3ksE"}}},"media_ids":["616849"],"groups":[],"categories":[],"keywords":[{"id":"960","name":"physics"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003Etara.davis@physics.gatech.edu\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}