{"626866":{"#nid":"626866","#data":{"type":"event","title":"Learning to Program Cellular Machines: Harnessing Cells to Treat Disease, Build Tissues, and Elucidate Design Principles","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EPetit Distinguished Lecture by Wendell Lim, University\u0026nbsp;of California, San Francisco\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nThe eras of molecular biology and genomics have given us an unprecedented picture of the molecular components underlying living systems. Nonetheless, our understanding of how these components are assembled to generate precision physiological systems remains far less developed. \u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETo approach this problem, we and others have been using synthetic biology methods to empirically explore how molecular components can be used to construct novel cellular functions. Using these approaches, we have shown that we can reprogram living cellular machines that carry out new precision functions, including therapeutic immune cells that precisely recognize and eliminate cancer cells, or cells that self-organize into tissues. \u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBy merging our understanding of cellular machines with our knowledge of our bodies and its diseases, we envision the development of a mature field of cell engineering with a toolbox of optimized molecular parts and circuit architectures, as well as disease and \u0026nbsp;\u0026quot;GPS\u0026quot; sensors that allow the cell to target specific sites in the body or brain. \u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESuch a platform will allow us to rapidly and flexibly prototype and design cells that can identify sites of disease or degeneration and execute precisely targeted and controlled therapeutic actions.\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EAbout the Speaker\u003C\/strong\u003E\u003Cem\u003E \u003C\/em\u003E\u003Cbr \/\u003E\r\nWendell Lim is the Byers Distinguished Professor and Chair of the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco. He is an Investigator of the Howard Hughes Medical Institute.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHe received his A.B. in Chemistry, summa cum laude, from Harvard College and\u0026nbsp;his Ph.D. in Biochemistry and Biophysics from he Massachusetts Institute of Technology. He completed postdoctoral training at Yale University.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHis research focuses on the design principles of molecular circuits that govern cell decision-making and responses. His lab has made contributions in understanding the molecular machinery of cell signaling and how molecular modules have been used in evolution to build novel new behaviors.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMost recently he has been a pioneer in the emerging field of synthetic biology, exploring how these design principles can be harnessed to engineer cells with customized therapeutic response programs. \u0026nbsp;He is an author of the textbook\u0026nbsp;\u0026quot;Cell Signaling\u0026quot; (Garland Science 2014) and was the founder of the cell therapy biotech startup\u0026nbsp;Cell Design Labs, which was acquired by Gilead Biosciences in 2017.\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EA community lunch will be served immediately after the lecture.\u003C\/strong\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Petit Distinguished Lecture by Wendell Lim, University of California, San Francisco"}],"uid":"30678","created_gmt":"2019-09-30 14:52:59","changed_gmt":"2019-09-30 14:52:59","author":"A. Maureen Rouhi","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-10-22T12:00:00-04:00","event_time_end":"2019-10-22T14:00:00-04:00","event_time_end_last":"2019-10-22T14:00:00-04:00","gmt_time_start":"2019-10-22 16:00:00","gmt_time_end":"2019-10-22 18:00:00","gmt_time_end_last":"2019-10-22 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"hg_media":{"615504":{"id":"615504","type":"image","title":"Wendell Lim, Ph.D. - University of California San Francisco","body":null,"created":"1545063734","gmt_created":"2018-12-17 16:22:14","changed":"1555347877","gmt_changed":"2019-04-15 17:04:37","alt":"","file":{"fid":"236234","name":"WendellLim.png","image_path":"\/sites\/default\/files\/images\/WendellLim.png","image_full_path":"http:\/\/tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/WendellLim.png","mime":"image\/png","size":312377,"path_740":"http:\/\/tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/WendellLim.png?itok=nkx93h_G"}}},"media_ids":["615504"],"related_links":[{"url":"http:\/\/cancer.ucsf.edu\/people\/profiles\/lim_wendell.4798","title":"Lim Profile"}],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"364801","name":"EAS"},{"id":"1275","name":"School of Biological Sciences"},{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"171033","name":"Synthetic Biology"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003Cbr \/\u003E\r\nEvents Manager\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}