{"667478":{"#nid":"667478","#data":{"type":"event","title":"PhD Proposal by Nia Myrie","body":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ENia Myrie\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EBME PhD Proposal Presentation\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003EDate\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E: 2023-05-04\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003ETime\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E: 9:00 - 11:00 am\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003ELocation \/ Meeting Link\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E: Pettit Microelectronics Building Room 102A; \u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/2503560220?pwd=K1RkcjVhM3VxNHFJV0xPQkt6Y3g0Zz09\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/2503560220?pwd=K1RkcjVhM3VxNHFJV0xPQkt6Y3g0Zz09\u003C\/a\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003ECommittee Members:\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cspan\u003EAndr\u00e9s J. Garc\u00eda, Ph.D. (Advisor); Young C. Jang, Ph.D.; Edward Botchwey, Ph.D.; Stanislav Emelianov, Ph.D.; Foteini Mourkioti, Ph.D.\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003ETitle\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E: Engineering a Synthetic Hydrogel for Muscle Stem Cell Delivery to Dystrophic Diaphragm\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003EAbstract:\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cspan\u003EDuchenne muscular dystrophy (DMD) is a genetic disorder caused by the absence of dystrophin protein, which serves as structural support between the muscle fiber membrane and extracellular matrix (ECM). Without it, muscles undergo cycles of degeneration and regeneration, leading to wasting and weakness. Overtime, DMD patients suffer from ambulatory disability and cardiorespiratory failure, the latter of which is a major contributor to premature death. Currently, there is no cure. Although glucocorticoid steroid treatment has lengthened patients\u2019 life span, this treatment has many negative side effects with short- and long-term use including furthering muscle weakness and atrophy. Gene therapies face obstacles related to mutation specificity and immunogenicity. An alternative treatment strategy is to transplant muscle satellite cells (MuSCs) to a target muscle to repopulate the stem cell niche and restore dystrophin to the muscle fibers. This strategy takes advantage of muscle cells\u2019 ability to fuse with existing muscle fibers, thus allowing dystrophin from donor cells to enter the fiber. MuSCs are typically delivered via injection; however, poor cell retention and survival upon transplantation ultimately leads to low cell engraftment and functionality. Delivering MuSCs to the diaphragm muscle poses additional challenges due to its morphology and deep-seated location. This project seeks to address these challenges by leveraging hydrogels as a vehicle for localized delivery. In Aim 1, I will engineer a peptide-functionalized synthetic hydrogel for localized MuSC delivery to dystrophic diaphragms. In Aim 2, I will assess the effects of delivering encapsulated MuSCs to dystrophic mice diaphragms by evaluating morphological and functional changes in the diaphragm. I hypothesize that these hydrogels will promote MuSC survival, proliferation, migration, and fusion for increased engraftment to host muscle, thus restoring dystrophin and improving diaphragm morphology and function. A successful outcome can contribute to future work furthering this platform as a therapy that extends and improves DMD patients\u2019 quality of life.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EGraduate Academic Office\u003C\/span\u003E\u003C\/strong\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cspan\u003E\u003Cspan\u003EGeorgia Institute of Technology \u0026amp; Emory University\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Ca href=\u0022mailto:GradAO@bme.gatech.edu\u0022\u003E\u003Cspan\u003EGradAO@bme.gatech.edu\u003C\/span\u003E\u003C\/a\u003E| 404-385-0124\u003C\/span\u003E\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EEngineering a Synthetic Hydrogel for Muscle Stem Cell Delivery to Dystrophic Diaphragm\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":" Engineering a Synthetic Hydrogel for Muscle Stem Cell Delivery to Dystrophic Diaphragm"}],"uid":"27707","created_gmt":"2023-04-22 00:15:13","changed_gmt":"2023-04-22 00:15:13","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-05-04T09:00:00-04:00","event_time_end":"2023-05-04T11:00:00-04:00","event_time_end_last":"2023-05-04T11:00:00-04:00","gmt_time_start":"2023-05-04 13:00:00","gmt_time_end":"2023-05-04 15:00:00","gmt_time_end_last":"2023-05-04 15:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Pettit Microelectronics Building Room 102A; ","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}