{"668041":{"#nid":"668041","#data":{"type":"event","title":"PhD Defense by Afsane Radmand","body":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EAfsane Radmand\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EBioE Ph.D. Defense Presentation\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ETime and Date:\u0026nbsp;\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E3:00 \u2013 5:00 PM, Thursday, June 22, 2023\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ELocation:\u0026nbsp;\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003EHSRB II, 1750 Haygood Drive, Atlanta, GA 30322, N600 (6th floor)\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EZoom Link:\u003C\/span\u003E\u003C\/strong\u003E\u0026nbsp;\u003Cspan\u003E\u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/3841552206\u0022 target=\u0022_blank\u0022\u003E\u003Cspan\u003Ehttps:\/\/gatech.zoom.us\/j\/3841552206\u003C\/span\u003E\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EPasscode\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E: 123 \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EAdvisor:\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EJames E. Dahlman, Ph.D. School of Biomedical engineering, \u003C\/span\u003E\u003Cspan\u003EGeorgia Institute of Technology and Emory University\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ECommittee Members:\u003C\/span\u003E\u003C\/strong\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EPhilip J. Santangelo, Ph.D.\u003C\/span\u003E\u003Cspan\u003E School of Biomedical engineering, \u003C\/span\u003E\u003Cspan\u003EGeorgia Institute of Technology and Emory University\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EJulie A. Champion, Ph.D. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EWilbur Lam, Ph.D. School of Biomedical Engineering, Georgia Institute of Technology and Emory University\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EBrandon Dixon, Ph.D. \u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003ESchool of Mechanical Engineering,\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003EGeorgia Institute of Technology\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ENext-generation lipid nanoparticle formulations for non-liver delivery of nucleic acid-based therapies and vaccines\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EThe clinical application of lipid nanoparticles (LNPs) delivering RNA-therapies has advanced remarkably over the past few decades with the Food and Drug Administration (FDA) approval of\u0026nbsp;\u003C\/span\u003E\u003Cspan\u003EONPATTRO\u00ae\u003C\/span\u003E\u003Cspan\u003E\u0026nbsp;in 2018 for treating a liver genetic disease following systemic administration and the most recent COVID-19 vaccines developed by\u0026nbsp;Moderna Therapeutics Inc. and Pfizer-BioNTech in 2021. Despite the success of first-generation LNP-RNA therapies, there is still a need to rationally design next-generation LNP formulations for systemic non-liver mRNA delivery and for vaccination against other malignant viruses such as respiratory syncytial virus (RSV).\u0026nbsp;In this work, we aimed to (i) identify helper lipid design rules and biological response for systemic lung mRNA delivery of LNPs, (ii) investigate the effect of cationic cholesterol in LNP formulation on systemic\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E\u0026nbsp;mRNA delivery, (iii) rationally enhance the immunogenicity of a developed mRNA-LNP RSV vaccine and (iv) develop a three-component stereopure mRNA-LNP vaccine to immunize against RSV. This work will establish the foundation towards achieving two crucial objectives: (1) exploiting lipid nanoparticle design rules for systemic\u0026nbsp;non-liver\u0026nbsp;delivery of RNA-based therapies and (2) determining factors for rational design of mRNA-LNP vaccines which will allow for taking a leap towards developing clinically relevant mRNA-based vaccines.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ENext-generation lipid nanoparticle formulations for non-liver delivery of nucleic acid-based therapies and vaccines\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Next-generation lipid nanoparticle formulations for non-liver delivery of nucleic acid-based therapies and vaccines"}],"uid":"27707","created_gmt":"2023-06-09 14:27:31","changed_gmt":"2023-06-09 14:27:31","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-06-22T15:00:01-04:00","event_time_end":"2023-06-22T17:00:00-04:00","event_time_end_last":"2023-06-22T17:00:00-04:00","gmt_time_start":"2023-06-22 19:00:01","gmt_time_end":"2023-06-22 21:00:00","gmt_time_end_last":"2023-06-22 21:00:00","rrule":null,"timezone":"America\/New_York"},"location":"HSRB I","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}