{"670788":{"#nid":"670788","#data":{"type":"event","title":"BioE PhD Defense Presentation- Sanchita Bhat","body":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EAdvisor: \u0026nbsp;\u003C\/span\u003E\u003C\/strong\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ELakshmi Prasad Dasi, Ph.D. (Georgia Institute of Technology)\u0026nbsp;\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ECommittee:\u0026nbsp;\u003C\/span\u003E\u003C\/strong\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EAjit P. Yoganathan, Ph.D. (Georgia Institute of Technology)\u0026nbsp;\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EChristopher Breuer, M.D. (Nationwide Children\u2019s Hospital)\u0026nbsp;\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ERudolph Gleason, Ph.D. (Georgia Institute of Technology)\u0026nbsp;\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EScott Hollister, Ph.D. (Georgia Institute of Technology)\u0026nbsp;\u003C\/span\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u0026nbsp;\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EDevelopment and Biomechanical Assessment of Heart Valve Replacements Designed for \u003Cem\u003EIn Utero \u003C\/em\u003EDeployment\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u2002\u2002\u2002\u2002\u2002\u2002Congenital heart diseases (CHDs) account for nearly one third of all congenital defects. Patients born with complex congenital cardiac anomalies often require heart valve replacements in their lifetimes. Prenatally,\u003Cspan\u003E\u0026nbsp;attempts have been made to restore biventricular healthy anatomy\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u0026nbsp;\u003Cem\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Ein utero\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/em\u003E\u003Cem\u003E\u0026nbsp;\u003C\/em\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Eby balloon valvuloplasty. A lot of patients that undergo this procedure develop re-atresia or re-stenosis, requiring valve replacements.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u0026nbsp;\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EThere has been an investigation into providing a permanent solution to heart valve replacements in children using tissue engineering. \u0027Neo-tissue\u0027 develops using the patient\u2019s own cells, and therefore eradicates the susceptibility of severe rejection possessing the ability to grow, repair and remodel.\u0026nbsp;Tissue engineering can be used as a viable tool in the fetal population due to the high regenerative capacity. This study developed a fetal transcatheter pulmonary valve replacement. T\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Ehe overall hypothesis is that \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Eimproved understanding of the biomechanics of manufacturing and testing of biodegradable materials can help engineer fetal sized tissue engineered heart valves (TEHVs) and guide future transcatheter device interventions\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E.\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u2002\u2002\u2002\u2002\u2002\u2002Specific Aim 1 shed light on the stress distributions and stent characteristics of candidate stent designs simulated with four candidate materials (metal and polymeric).\u0026nbsp; \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EResults showed differences in stress distributions and stent performance metrics (dog boning, foreshortening and recoil) in the three designs. Both metals performed favorably, although polymer performance (due to high elastic modulus) was better suited to current designs. It was also shown that design had a great effect on distribution of high stresses and c\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Eomposite materials need to be explored in the future to combine the advantages of both metals and polymers.\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ESpecific Aim 2 developed and tested\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Ealternative sutureless valve assembly techniques that can overcome potential premature failure of valves and benchtop tested patterns of leaflet degradation. Results showed that changing the material density in the valve assembly can help control degradation and performance of the valve\u003Cem\u003E in vivo\u003C\/em\u003E. Specific Aim 3 looked at\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Efetal valve hemodynamic performance and downstream fluid profiles in a pulse duplicator and durability in an AWT. Results showed that although performance values differ between prototypes, all performed well individually and durability in a non-degrading medium was high, indicating the possible longevity of valve \u003Cem\u003Ein vivo.\u003C\/em\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u2002\u2002\u2002\u2002\u2002\u2002T\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Ehe development of such a TEHV will eliminate the need for repeat interventions and serve as a permanent alternative. Given the few durable options for pediatric patients, this study will improve the feasibility of developing such a device right from the manufacturing to the testing stage. This critical integration of heart valve and tissue\u0026nbsp;engineering may be the first step to the solution that is needed to reverse ventricular hypoplasia and eliminate single ventricle anomalies.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Presentation- \u0022Development and Biomechanical Assessment of Heart Valve Replacements Designed for In Utero Deployment \u0022 -Sanchita Bhat\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Development and Biomechanical Assessment of Heart Valve Replacements Designed for In Utero Deployment \u0022"}],"uid":"27917","created_gmt":"2023-10-31 13:03:08","changed_gmt":"2023-10-31 13:03:08","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-11-13T13:30:00-05:00","event_time_end":"2023-11-13T15:30:00-05:00","event_time_end_last":"2023-11-13T15:30:00-05:00","gmt_time_start":"2023-11-13 18:30:00","gmt_time_end":"2023-11-13 20:30:00","gmt_time_end_last":"2023-11-13 20:30:00","rrule":null,"timezone":"America\/New_York"},"location":"IBB Rm 2316 ","extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}