{"671364":{"#nid":"671364","#data":{"type":"event","title":"PhD Defense by Biaggio Uricoli","body":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EBiaggio Uricoli\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EBME PhD Defense Presentation\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EDate\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E: 2023-12-05\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ETime\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E: 1:00 PM - 2:30 PM\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ELocation \/ Meeting Link\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E: EBB 5029 \/ \u003Ca href=\u0022https:\/\/us06web.zoom.us\/j\/87590494866\u0022\u003Ehttps:\/\/us06web.zoom.us\/j\/87590494866\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ECommittee Members:\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EErik Dreaden, PhD (Co-Advisor); Krishnendu Roy, PhD (Co-Advisor); Wilbur Lam, MD\/PhD; Christopher Porter, MD; Sarwish Rafiq, PhD; Khalid Salaita, PhD\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ETitle\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E: Multivalent Immunomodulators for CAR T Cell Manufacturing and T Cell-Engager Immunotherapy\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EAbstract:\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ECancer immunotherapy, a treatment strategy in which immune cells are directed to eliminate cancer cells, represents an established therapeutic approach with a growing range of modalities and addressable disease indications. Two forms of cancer immunotherapy, chimeric antigen receptor (CAR) T cells and bi-specific T cell engagers (BiTEs), induce the clearance of malignant cells via CAR- or drug- induced T cell cytolysis, respectively. These treatments have generated promising initial responses in patients with B cell malignancies but can fail to achieve durable treatment responses following therapy. Methods to thus improve CAR T cell persistence or to enhance BiTE-mediated cytolysis of cancer cells represent an urgent and unmet clinical need. To address this need, our laboratory developed a strategy for the rapid assembly and screening of compositionally diverse libraries of IgG-conjugated, multivalent immunomodulating nanoparticles, employing it for the identification of cytokine-modified BiTEs with lytic activity comparable to FDA-approved immunotherapies. Here, we adapted this rapid assembly and screening approach to identify multivalent micro- and nano- particles that 1) selectively expanded efficacious and long-lived subsets of CAR T cells during manufacturing and 2) acted as potent BiTE immunotherapies in cell culture cytotoxicity assays incorporating B cell cancers. In this work, we studied the therapeutic impact of these new compounds 1) on the targeting, persistence, and efficacy of CAR T cell immunotherapy in mouse models of B cell malignancies and 2) as liposomal and iron oxide BiTEs for induction of malignant B cell death ex vivo. Following completion, this work presented a multivalent particle discovery platform for the identification of novel immunotherapeutics and generated new immunomodulators with the potential to improve treatment outcomes for patients with B cell malignancies.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EMultivalent Immunomodulators for CAR T Cell Manufacturing and T Cell-Engager Immunotherapy\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Multivalent Immunomodulators for CAR T Cell Manufacturing and T Cell-Engager Immunotherapy"}],"uid":"27707","created_gmt":"2023-12-01 20:24:17","changed_gmt":"2023-12-01 20:24:17","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-12-05T13:00:00-05:00","event_time_end":"2023-12-05T15:00:00-05:00","event_time_end_last":"2023-12-05T15:00:00-05:00","gmt_time_start":"2023-12-05 18:00:00","gmt_time_end":"2023-12-05 20:00:00","gmt_time_end_last":"2023-12-05 20:00:00","rrule":null,"timezone":"America\/New_York"},"location":" EBB 5029 \/ ","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}