{"88861":{"#nid":"88861","#data":{"type":"event","title":"(11-1128)  Dr. Delai Chen, Massachusetts Institute of Tech.","body":[{"value":"\u003Cp\u003EDr. Delai Chen, Massachusetts Institute of Technology\n\u003C\/p\u003E\n\u003Cp\u003EMicrofluidic tools for high throughput chemistry and biotechnology\n\u003C\/p\u003E\n\u003Cp\u003EThe intrinsic advantages that microfluidic tools afford \u00e2\u0080\u0022 miniaturization, compartmentalization, and improved control of solution mixing \u00e2\u0080\u0022 enable a host of chemical and biotechnological applications, including massively parallel, nanoliter-scale organic reactions and improved methods for protein crystallography. Compartmentalization of solutions into droplets also allows chemical signals to be transported without dispersion, a property that was utilized to develop the \u00e2\u0080\u009cchemistrode\u00e2\u0080\u009d \u00e2\u0080\u0022 the chemical analog of an electrode. The chemistrode can chemically stimulate and sample a biological surface with high spatial and temporal resolution, and enables off-line analysis of the recorded dynamic molecular signals.  Measurement of insulin secretion from a single pancreatic islet with 1.5-second time resolution was demonstrated using the chemistrode. To facilitate high-throughput screening of reagents for small-interfering RNA (siRNA) delivery, a microfluidic mixing device was designed to rapidly formulate lipid-siRNA nanoparticles with improved control over particle sizes. This formulation approach offered novel insights into the high-throughput screening process that led to the discovery of potent non-viral reagents for siRNA and DNA delivery. Future research in microfluidics will continue to increase the impact of these tools, ushering in next generation disease diagnostics and therapeutics, as well as basic discoveries in the organizing principles of biology.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:lyon@chemistry.gatech.edu\u0022\u003EProf. Andrew Lyon\u003C\/a\u003E (404-894-4090).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Dr. Delai Chen, Massachusetts Institute of Technology\n\nMicrofluidic tools for high throughput chemistry and biotechnology","format":"limited_html"}],"field_summary_sentence":[{"value":"Dr. Delai Chen, Massachusetts Institute of Tech."}],"uid":"27275","created_gmt":"2011-10-10 00:00:00","changed_gmt":"2016-10-08 01:50:53","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-11-28T15:00:00-05:00","event_time_end":"2011-11-28T16:00:00-05:00","event_time_end_last":"2011-11-28T16:00:00-05:00","gmt_time_start":"2011-11-28 20:00:00","gmt_time_end":"2011-11-28 21:00:00","gmt_time_end_last":"2011-11-28 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"919","name":"Biochemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}