{"89921":{"#nid":"89921","#data":{"type":"event","title":"(11-0207) Prof. Nicole Sampson, Stony Brook University","body":[{"value":"\u003Cp\u003EProf. Nicole Sampson, Stony Brook University\n\u003C\/p\u003E\n\u003Cp\u003EMycobacteria on Steroids: Metabolomics and Pathogenesis\n\u003C\/p\u003E\n\u003Cp\u003ENew drugs with novel mechanisms of action are required to meet the severe threat to human health posed by the emergence of multidrug and extensively drug resistant strains of M. tuberculosis (M. tb).  The ability of M. tb to metabolize cholesterol is critical for the maintenance of the M. tb infection; both the igr operon and fadA5 are required for in vitro growth using cholesterol as a sole carbon source.  However, mutation of these genes involved in cholesterol metabolism results in different in vivo phenotypes.  We are elucidating the function of these genes, their corresponding enzymes, and their role in cholesterol metabolism using a combination of transcriptional profiling, bioinformatics, enzymology, biochemistry, and metabolic phenotype screening.  Ultimately, understanding cholesterol metabolism at the molecular level will direct drug discovery towards novel targets that attenuate M. tb growth and persistence in vivo.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:lyon@chemistry.gatech.edu\u0022\u003EProf. Andrew Lyon\u003C\/a\u003E (404-894-4090).\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Nicole Sampson, Stony Brook University\n\nMycobacteria on Steroids: Metabolomics and Pathogenesis","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Nicole Sampson, Stony Brook University"}],"uid":"27275","created_gmt":"2011-01-06 01:00:00","changed_gmt":"2016-10-08 01:46:44","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-02-07T15:00:00-05:00","event_time_end":"2011-02-07T16:00:00-05:00","event_time_end_last":"2011-02-07T16:00:00-05:00","gmt_time_start":"2011-02-07 20:00:00","gmt_time_end":"2011-02-07 21:00:00","gmt_time_end_last":"2011-02-07 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.stonybrook.edu\/nsampson.html","title":"Dr. Nicole Sampson"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"919","name":"Biochemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}