{"90391":{"#nid":"90391","#data":{"type":"event","title":"(10-1105) Prof. Donald Burke, University of Missouri","body":[{"value":"\u003Cp\u003EProf. Donald Burke, University of Missouri\n\u003C\/p\u003E\n\u003Cp\u003EArtificial genetics and metabolisms catalyzed by RNA\n\u003C\/p\u003E\n\u003Cp\u003EBiochemistry Division Seminar Series\u003Cbr \/\u003E\nRiboEvo Special Seminar\n\u003C\/p\u003E\n\u003Cp\u003E RNA catalysis offers an attractive tool for synthetic biologies and is at the heart of most speculations on the nature of ancient life. The last two decades have begun to put foundations under these speculations, replacing fantasy with experimental constraints. It is now recognized that\u00e2\u0080\u0022if provided with suitably activated mononucleotides\u00e2\u0080\u0022ribozymes can catalyze all of the subsequent reactions required for the transmission of genetic information. They can bind primer-template substrate for polymerization and extend the substrate more than one complete helical turn. They can use the energy of an NTP to activate an organic acid or amino acid. They can then use the activated compound in acyl transfers to generate thioesters, ribose esters, amides and peptide bonds. Because energy capture is critical to substrate activation and subsequent reactivity, this talk will emphasize our recent studies of phosphoryl transfer ribozymes. Some of the current research frontiers in this area include building more complex ribozyme networks that control metabolite flux, productively incorporating rational design into ribozyme selection strategies, blending in vitro selections with engineered and synthetic biologies, and defining the role(s) of separable substrate-binding and catalytic modules in ribozyme evolution.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact Prof. Loren Williams (404-894-9752).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Donald Burke, University of Missouri\n\nArtificial genetics and metabolisms catalyzed by RNA\n\nBiochemistry Division Seminar Series\nRiboEvo Special Seminar","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Donald Burke, University of Missouri"}],"uid":"27275","created_gmt":"2010-05-24 00:00:00","changed_gmt":"2016-10-08 01:47:17","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2010-11-05T17:00:00-04:00","event_time_end":"2010-11-05T18:00:00-04:00","event_time_end_last":"2010-11-05T18:00:00-04:00","gmt_time_start":"2010-11-05 21:00:00","gmt_time_end":"2010-11-05 22:00:00","gmt_time_end_last":"2010-11-05 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/biochem.missouri.edu\/faculty\/faculty-members\/burked\/index.php","title":"Prof. Donald Burke, University of Missouri"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"167061","name":"symposium"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}