{"90711":{"#nid":"90711","#data":{"type":"event","title":"(11-0215) Prof. Kevin Bucholtz, Mercer University","body":[{"value":"\u003Cp\u003E Prof. Kevin Bucholtz, Mercer University\n\u003C\/p\u003E\n\u003Cp\u003EPPAR \u00ce\u00b4 and 3\u00ce\u00b2-HSD1: Two Stories in Ligand Selectivity\n\u003C\/p\u003E\n\u003Cp\u003EOrganic Chemistry Seminar Series\n\u003C\/p\u003E\n\u003Cp\u003EPeroxisome Proliferator Activated Receptors (PPAR) are nuclear hormone receptors that are of great interest because of their implications in the metabolic syndrome.  The isotype PPAR \u00ce\u00b4, a ligand activated transcription factor, is of significant interest since little is known about its role in biological phenomena.  The human type isoform of 3\u00ce\u00b2-hydroxysteroid dehydrogenase\/ isomerase (3\u00ce\u00b2-HSD1) is a key enzyme in the biosynthesis of active steroid hormones. Human 3\u00ce\u00b2-HSD1 is a critical enzyme in the conversion of dehydroepiandrosterone (DHEA) to estradiol in breast tumors.   Both of these biomacromolecules (PPAR \u00ce\u00b4 and 3\u00ce\u00b2-HSD1)  have been the focus of rationally designed small molecules to selectively interact with each target and used to determine the characteristics of the interaction.  The biological implications of these small molecule interactions are currently being investigated.\n\u003C\/p\u003E\n\u003Cp\u003Efor more information contact \u003Ca href=\u0022mailto:wendy.kelly@chemistry.gatech.edu\u0022\u003EProf. Wendy Kelly\u003C\/a\u003E (404-385-1154).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Kevin Bucholtz, Mercer University\n\nPPAR \u00ce\u00b4 and 3\u00ce\u00b2-HSD1: Two Stories in Ligand Selectivity\n\nOrganic Chemistry Seminar Series","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Kevin Bucholtz, Mercer University"}],"uid":"27275","created_gmt":"2010-05-06 00:00:00","changed_gmt":"2016-10-08 01:47:45","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-02-15T15:00:00-05:00","event_time_end":"2011-02-15T16:00:00-05:00","event_time_end_last":"2011-02-15T16:00:00-05:00","gmt_time_start":"2011-02-15 20:00:00","gmt_time_end":"2011-02-15 21:00:00","gmt_time_end_last":"2011-02-15 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/chemistry.mercer.edu\/fackmb.htm","title":"Prof. Kevin Bucholtz, Mercer University"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"919","name":"Biochemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}