{"90851":{"#nid":"90851","#data":{"type":"event","title":"(10-0412) Prof. Barbara Shaw, Duke University","body":[{"value":"\u003Cp\u003EProf. Barbara Shaw, Duke University\n\u003C\/p\u003E\n\u003Cp\u003ECoding, Decoding, and Modulating Genetic Information with Boranophospate Mimics of Nucleotides, DNA and RNA\n\u003C\/p\u003E\n\u003Cp\u003EBiochemistry Seminar Series\n\u003C\/p\u003E\n\u003Cp\u003EThe P-boranophosphates are efficient and near perfect mimics of natural nucleic acids in permitting reading and writing of genetic information with high yield and accuracy.  Substitution of a borane (\u00e2\u0080\u0022BH\u003Csub\u003E3\u003C\/sub\u003E) group for oxygen in the phosphate ester bond creates near perfect isoelectronic and isosteric mimics of naturally evolved nucleotide phosphate esters found in mono, di, trinucleotides (AMP, ADP, ATP) and in RNA and DNA.  Relative to naturally evolved nucleic acids, the borane-containing DNA and RNA analogues demonstrate increased lipophilicity and resistance to endo- and exonucleases, yet they retain a negative charge and similar spatial geometry.  Borane NTPs have the ability to serve as good substrates for naturally evolved nucleotides (like ATP and dATP) and as templates in replication, transcription and reverse transcription.  We are exploring their use in aptamer selection, and antiviral, antisense, and RNAi therapeutics.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:loren.willliams@chemistry.gatech.edu\u0022\u003EProf. Loren Williams\u003C\/a\u003E (404-894-9752).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Barbara Shaw, Duke University\n\nCoding, Decoding, and Modulating Genetic Information with Boranophospate Mimics of Nucleotides, DNA and RNA\n\nBiochemistry Seminar Series","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Barbara Shaw, Duke University"}],"uid":"27275","created_gmt":"2010-03-03 01:00:00","changed_gmt":"2016-10-08 01:48:11","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2010-04-12T16:00:00-04:00","event_time_end":"2010-04-12T17:00:00-04:00","event_time_end_last":"2010-04-12T17:00:00-04:00","gmt_time_start":"2010-04-12 20:00:00","gmt_time_end":"2010-04-12 21:00:00","gmt_time_end_last":"2010-04-12 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/fds.duke.edu\/db\/aas\/Chemistry\/faculty\/barbara.r.shaw","title":"Prof. Barbara Shaw, Duke University"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"1809","name":"physical chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}