{"92481":{"#nid":"92481","#data":{"type":"event","title":"(09-0421) Spicer Lecture, Prof. R. Mark Wightman, UNC Chapel Hill","body":[{"value":"\u003Cp\u003ESpicer Lecture, Prof. R. Mark Wightman, UNC Chapel Hill\n\u003C\/p\u003E\n\u003Cp\u003EVoltammetric Measurements of Rapid Chemical Signalling in the Brain by Dopamine\n\u003C\/p\u003E\n\u003Cp\u003ENeurotransmitters such as dopamine relay information between neurons.  Using carbon-fiber microelectrodes we have developed a voltammetric-based sensing scheme to monitor dopamine in the brain during behaviour.  The electrodes have micron dimensions and can be used on millisecond time scales.  The voltammetric data is evaluated with principal component regression and multiple contributors to the electrochemical signals can be resolved.  Furthermore, the electrodes can be used in an electrophysiological mode to sense the transient voltages that arise from neuronal firing.  When the electrode is alternated between electrophysiological and chemical sensing on a subsecond time scale, a complete picture of the fluctuations of dopamine and its actions on adjacent neurons can be determined.  These real-time measurements provide an entirely new view of the role of dopamine in the brain.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:carrie.shepler@chemistry.gatech.edu\u0022\u003EDr. Carrie Shepler\u003C\/a\u003E (404-385-1342).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Spicer Lecture, Prof. R. Mark Wightman, UNC Chapel Hill\n\nVoltammetric Measurements of Rapid Chemical Signalling in the Brain by Dopamine","format":"limited_html"}],"field_summary_sentence":[{"value":"Spicer Lecture, Prof. R. Mark Wightman, UNC Chapel Hill"}],"uid":"27275","created_gmt":"2008-12-23 01:00:00","changed_gmt":"2016-10-08 01:57:16","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2009-04-21T16:00:00-04:00","event_time_end":"2009-04-21T17:00:00-04:00","event_time_end_last":"2009-04-21T17:00:00-04:00","gmt_time_start":"2009-04-21 20:00:00","gmt_time_end":"2009-04-21 21:00:00","gmt_time_end_last":"2009-04-21 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.unc.edu\/people\/faculty\/wightman\/index.html","title":"Prof. Mark Wightman, UNC Chapel Hill"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"1809","name":"physical chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}