{"92921":{"#nid":"92921","#data":{"type":"event","title":"(08-1017) Prof. Jack Summers, Western Carolina University","body":[{"value":"\u003Cp\u003EProf. Jack Summers, Western Carolina University\n\u003C\/p\u003E\n\u003Cp\u003EStudies of metal\/anion interactions relevant to biological oxidative stress\n\u003C\/p\u003E\n\u003Cp\u003EInorganic division seminar\n\u003C\/p\u003E\n\u003Cp\u003EReactions of metal complexes with superoxide anion are fundamentally important to biological oxidative stress.  Reductions of metal complexes by superoxide (believed to be the limiting step in ROS production) have long been thought to proceed by an outer-sphere mechanism.  Using NMR spectrometry, we have measured rates of metal \/ anion association for a variety of iron and manganese complexes and have found that these rates correlate well with rates at which the metal complexes react with superoxide.  We believe this is strong evidence that these reactions proceed by an inner-sphere mechanism.  Based on this evidence, we propose simple experimental methods for predicting metal \/ superoxide reactivities.  Ongoing research in the Summers\u0027 lab includes using these methods to study small molecule inhibition of superoxide dismutases enzymes and mechanisms of antibacterial actions of certain clays. \n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:jake.soper@chemistry.gatech.edu\u0022\u003EProf. Jake Soper\u003C\/a\u003E (404-894-4022).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Jack Summers, Western Carolina University\n\nStudies of metal\/anion interactions relevant to biological oxidative stress\n\nInorganic division seminar","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Jack Summers, Western Carolina University"}],"uid":"27275","created_gmt":"2008-08-05 00:00:00","changed_gmt":"2016-10-08 01:57:20","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2008-10-17T16:00:00-04:00","event_time_end":"2008-10-17T17:00:00-04:00","event_time_end_last":"2008-10-17T17:00:00-04:00","gmt_time_start":"2008-10-17 20:00:00","gmt_time_end":"2008-10-17 21:00:00","gmt_time_end_last":"2008-10-17 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.wcu.edu\/4462.asp","title":"Prof. Jack Summers, Western Carolina University"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"4910","name":"inorganic chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}