{"95221":{"#nid":"95221","#data":{"type":"event","title":"(0425) Dr. Angelo Bongiorno, GIT","body":[{"value":"\u003Cp\u003EDr. Angelo Bongiorno, Georgia Tech, School of Physics\n\u003C\/p\u003E\n\u003Cp\u003EOxidative damage to DNA: role of sequence and strand direction\n\u003C\/p\u003E\n\u003Cp\u003EABSTRACT\n\u003C\/p\u003E\n\u003Cp\u003ESpontaneous oxidation of guanine residues in DNA generates 8-oxoguanine, a lesion related to carcinogenesis and aging. In this lecture, I presenta quantum mechanics\/molecular mechanics (QM\/MM) investigation of the oxidative damage caused by the reaction of water with ionized DNA. The results of the atomistic simulations elucidate the puzzling experimental evidence of an oxidative damage rate depending on the DNA sequence and strand direction.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:hernandez@chemistry.gatech.edu\u0022\u003EDr. Rig Hernandez\u003C\/a\u003E (404-894-0594).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Dr. Angelo Bongiorno, Georgia Tech, School of Physics","format":"limited_html"}],"field_summary_sentence":[{"value":"Dr. Angelo Bongiorno, Georgia Tech"}],"uid":"27275","created_gmt":"2006-04-21 00:00:00","changed_gmt":"2016-10-08 01:57:36","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2006-04-25T17:00:00-04:00","event_time_end":"2006-04-25T18:00:00-04:00","event_time_end_last":"2006-04-25T18:00:00-04:00","gmt_time_start":"2006-04-25 21:00:00","gmt_time_end":"2006-04-25 22:00:00","gmt_time_end_last":"2006-04-25 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"89","name":"chemistry"},{"id":"4304","name":"organic chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}